Hypothalamic regulation of adiposity:: The role of 11β-hydroxysteroid dehydrogenase type 1

被引：18

作者：

Hochberg, Z ^{[1
]}

Friedberg, M ^{[1
]}

Yaniv, L ^{[1
]}

Bader, T ^{[1
]}

Tiosano, D ^{[1
]}

机构：

[1] Meyer Childrens Hosp, Rambam Med Ctr, Div Endocrinol, IL-31096 Haifa, Israel

来源：

HORMONE AND METABOLIC RESEARCH | 2004年 / 36卷 / 06期

关键词：

hypothalamus; obesity; 11 beta-hydroxysteroid dehydrogenase; adipocyte;

D O I：

10.1055/s-2004-814570

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Following extensive suprasellar operations for excision of hypothalamic tumors, some patients develop morbid obesity despite receiving replacement doses of glucocorticoids. Urine analysis of cortisol and cortisone metabolites show that 11-OH/11-oxo ratios are significantly higher in patients with hypothalamic obesity, indicating enhanced 11 beta-HSD1 activity. This correlates with the visceral-to-subcutaneous fat ratio. The consequence of increased 11beta-HSD1 activity and a shift of the steroid inter-conversion towards cortisol may contribute to the effects of the latter in adipose tissue. The message from the hypothalamus to adipocyte 11beta-HSD-1 involves hormones, the sympathetic nervous system and cytokines. CRH and ACTH downregulate 11beta-HSD-1 activity and induce lipolysis. Tumor necrosis factor-alpha, and interleukin-1beta upregulate 11beta-HSD-1 expression and activity, while enhancing lipolysis. The sympathetic nervous system exerts its effects through beta-adrenergic upregulation and alpha-adrenergic downregulation of 11beta-HSD-1 activity. Inhibition of 11beta-HSD-1 suppresses preadipocyte differentiation into mature adipocytes, and may provide a therapeutic tool.

引用

页码：365 / 369

页数：5

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