Gold-Catalyzed Cascade Cyclization of (Azido)ynamides: An Efficient Strategy for the Construction of Indoloquinolines

被引：129
作者：
Tokimizu, Yusuke [1 ]
Oishi, Shinya [1 ]
Fujii, Nobutaka [1 ]
Ohno, Hiroaki [1 ]
机构：
[1] Kyoto Univ, Grad Sch Pharmaceut Sci, Sakyo Ku, Kyoto 6068501, Japan
来源：
ORGANIC LETTERS | 2014年 / 16卷 / 11期
基金：
日本学术振兴会;
关键词：
DIRECT ALKYNYLATION; IN-VITRO; ALKYNES; ACTIVATION; INSIGHTS; ACCESS; NEOCRYPTOLEPINES; (-)-QUINOCARCIN; HYDROARYLATION; ENYNES;
D O I：
10.1021/ol5012604
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
(Azido)ynamides were efficiently converted into indoloquinolines by the use of a gold catalyst. While ynamides bearing an allylsilane gave terminal alkenes, ynamides bearing a simple alkene gave cyclopropanes. This reaction proceeds through the formation of an alpha-amidino gold carbenoid.
引用
收藏
页码：3138 / 3141
页数：4
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