Gold-Catalyzed Cascade Cyclization of (Azido)ynamides: An Efficient Strategy for the Construction of Indoloquinolines

被引：130

作者：

Tokimizu, Yusuke ^{[1
]}

Oishi, Shinya ^{[1
]}

Fujii, Nobutaka ^{[1
]}

Ohno, Hiroaki ^{[1
]}

机构：

[1] Kyoto Univ, Grad Sch Pharmaceut Sci, Sakyo Ku, Kyoto 6068501, Japan

来源：

ORGANIC LETTERS | 2014年 / 16卷 / 11期

基金：

日本学术振兴会;

关键词：

DIRECT ALKYNYLATION; IN-VITRO; ALKYNES; ACTIVATION; INSIGHTS; ACCESS; NEOCRYPTOLEPINES; (-)-QUINOCARCIN; HYDROARYLATION; ENYNES;

D O I：

10.1021/ol5012604

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

(Azido)ynamides were efficiently converted into indoloquinolines by the use of a gold catalyst. While ynamides bearing an allylsilane gave terminal alkenes, ynamides bearing a simple alkene gave cyclopropanes. This reaction proceeds through the formation of an alpha-amidino gold carbenoid.

引用

页码：3138 / 3141

页数：4

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