Functional phenotyping and genotyping of circulating tumor cells from patients with castration resistant prostate cancer

被引：66

作者：

Paris, Pamela L. ^{[1
]}

Kobayashi, Yasuko ^{[1
]}

Zhao, Qiang ^{[2
]}

Zeng, Wei ^{[3
]}

Sridharan, Shivaranjani ^{[1
]}

Fan, Tina ^{[2
]}

Adler, Howard L. ^{[2
]}

Yera, Emmanuel R. ^{[1
]}

Zarrabi, M. H. ^{[4
]}

Zucker, Stanley ^{[4
]}

Simko, Jeffry ^{[1
]}

Chen, Wen-Tien ^{[2
,3
]}

Rosenberg, Jonathan ^{[5
]}

机构：

[1] Univ Calif San Francisco, Dept Urol, San Francisco, CA 94143 USA

[2] SUNY Stony Brook, Ctr Canc, Stony Brook, NY 11794 USA

[3] Vitatex Inc, Stony Brook, NY 11790 USA

[4] Vet Adm Med Ctr, Northport, NY 11768 USA

[5] Univ Calif San Francisco, Div Hematol & Oncol, San Francisco, CA 94115 USA

来源：

CANCER LETTERS | 2009年 / 277卷 / 02期

关键词：

Prostate cancer; Metastasis; Circulating tumor cells; Blood micrometastases; DNA COPY NUMBER; COMPARATIVE GENOMIC HYBRIDIZATION; HIGH-RESOLUTION ANALYSIS; BREAST-CANCER; PERIPHERAL-BLOOD; OLIGONUCLEOTIDE CGH; ADHESION MOLECULE; BONE-MARROW; METASTASIS; ARRAY;

D O I：

10.1016/j.canlet.2008.12.007

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Circulating tumor cells (CTCs) hold promise for studying advanced prostate cancer. A functional collagen adhesion matrix (CAM) assay was used to enrich CTCs from prostate cancer patients' blood. CAM ingestion and epithelial immuno-staining identified CTCs, which were genotyped using oligonucleotide array comparative genomic hybridization. The highest CTC counts were observed in men with metastatic castration resistant prostate cancer (CRPC) compared to castration sensitive prostate cancer. Copy number profiles for CRPC CTCs were similar to paired solid tumor DNA, and distinct from corresponding DNA from the residual CAM-depleted blood. CAM CTC enrichment may allow cellular and genetic analyses in prostate cancer. (c) 2008 Elsevier Ireland Ltd. All rights reserved.

引用

页码：164 / 173

页数：10

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