The Future of TB Resistance Diagnosis: The Essentials on Whole Genome Sequencing and Rapid Testing Methods

被引：6

作者：

Moreno-Molina, Miguel ^{[1
]}

Comas, Inaki ^{[1
,2
]}

Furio, Victoria ^{[1
]}

机构：

[1] Biomed Inst Valencia CSIC, Valencia, Spain

[2] CIBER Epidemiol & Publ Hlth, Madrid, Spain

来源：

ARCHIVOS DE BRONCONEUMOLOGIA | 2019年 / 55卷 / 08期

关键词：

Mycobacterium tuberculosis; Antibiotic resistance; Whole genome sequencing; Precision medicine; Rapid diagnostics; PARA-AMINOSALICYLIC ACID; MYCOBACTERIUM-TUBERCULOSIS; ANTIBIOTIC-RESISTANCE; ISONIAZID RESISTANCE; DRUG-RESISTANCE; MUTATIONS; SUSCEPTIBILITY; STREPTOMYCIN; GENE; SURVEILLANCE;

D O I：

10.1016/j.arbres.2019.01.002

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

Tuberculosis resistance diagnostics have vastly improved in recent years thanks to the development of standardised phenotypic and molecular testing methods. However, these methods are either slow or limited in the number of resistant genotypes they can detect. With the advent of next-generation sequencing (NGS) we can sidestep all those problems, as we can sequence whole tuberculosis genomes at increasingly smaller costs and requiring less and less DNA. In this review, we explain how accumulated knowledge in the field has allowed us to go from phenotypic testing to molecular methods to Whole Genome Sequencing (WGS) for resistance diagnostics. We compare current diagnostic methods with WGS as to their efficacy in detecting resistant cases, and show how forthcoming advances in NGS technologies will be crucial in widespread implementation of WGS as a diagnostic tool. (C) 2019 SEPAR. Published by Elsevier Espana, S.L.U. All rights reserved.

引用

页码：421 / 426

页数：6

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