Estimation of kinetic parameters in an S-system equation model for a metabolic reaction system using the Newton-Raphson method

被引：11

作者：

Iwata, Michio ^{[1
]}

Sriyudthsak, Kansuporn ^{[2
,3
]}

Hirai, Masami Yokota ^{[2
,3
]}

Shiraishi, Fumihide ^{[1
]}

机构：

[1] Kyushu Univ, Grad Sch Bioresource & Bioenvironm Sci, Dept Biosci & Biotechnol, Sect Bioproc Design,Higashi Ku, Fukuoka 8208581, Japan

[2] RIKEN Ctr Sustainable Resource Sci, Yokohama, Kanagawa 2300045, Japan

[3] JST, CREST, Kawaguchi, Saitama 3320012, Japan

来源：

MATHEMATICAL BIOSCIENCES | 2014年 / 248卷

基金：

日本学术振兴会;

关键词：

Biochemical systems theory; Newton-Raphson method; Parameter estimation; Time course data; TRICARBOXYLIC-ACID CYCLE; DICTYOSTELIUM-DISCOIDEUM; STEADY-STATE; LAW; OPTIMIZATION;

D O I：

10.1016/j.mbs.2013.11.002

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Metabolic reaction systems can be modeled easily in terms of S-system type equations if their metabolic maps are available. This study therefore proposes a method for estimating parameters in decoupled S-system equations on the basis of the Newton-Raphson method and elucidates the performance of this estimation method. Parameter estimation from the time-course data of metabolite concentrations reveals that the parameters estimated are highly accurate, indicating that the estimation algorithm has been constructed correctly. The number of iterations is small and the calculation converges in a very short time (usually less than 1 s). The method is also applied to time course data with noise and found to estimate parameters efficiently. Results indicate that the present method has the potential to be extended to a method for estimating parameters in large-scale metabolic reaction systems. (C) 2013 Elsevier Inc. All rights reserved.

引用

页码：11 / 21

页数：11

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