Sulfonyl azide-mediated norbornene aziridination for orthogonal peptide and protein labeling

被引：10

作者：

Gattner, Michael J. ^{[1
]}

Ehrlich, Michael ^{[1
]}

Vrabel, Milan ^{[1
]}

机构：

[1] Univ Munich, Dept Chem, D-81377 Munich, Germany

来源：

CHEMICAL COMMUNICATIONS | 2014年 / 50卷 / 83期

关键词：

DIELS-ALDER REACTIONS; TRANSFER-RNA SYNTHETASE; FREE CLICK CHEMISTRY; AMINO-ACIDS; GENETIC-CODE; ALKYNE CYCLOADDITION; PHOTOCLICK-CHEMISTRY; MAMMALIAN-CELLS; LIGATION; STRATEGIES;

D O I：

10.1039/c4cc04117h

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We describe a new bioconjugation reaction based on the aziridination of norbornenes using electron-deficient sulfonyl azides. The reaction enables to attach various useful tags to peptides and proteins under mild conditions.

引用

收藏

页码：12568 / 12571

页数：4

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