Synthesis and characterization of glucosamine-bound near-infrared probes for optical imaging

被引：59

作者：

Li, Cong ^{[1
]}

Greenwood, Tiffany R. ^{[1
]}

Bhujwalla, Zaver M. ^{[1
]}

Glunde, Kristine ^{[1
]}

机构：

[1] Johns Hopkins Univ, Sch Med, Russell H Morgan Dept Radiol & Radiol Sci, JHU,ICMIC Program, Baltimore, MD 21205 USA

来源：

ORGANIC LETTERS | 2006年 / 8卷 / 17期

关键词：

D O I：

10.1021/ol060783e

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Two novel near-infrared (NIR) fluorescent probes have been synthesized by linking a carbocyanine fluorophore and glucosamine through different linkers. These probes demonstrated a high quantum yield, low cytotoxicity, reversible pH-dependent fluorescence in the physiological pH range, and a decreased aggregation tendency in aqueous solutions. In vitro NIR optical imaging studies revealed cellular uptake and strong intracellular NIR fluorescence of these two probes in four breast epithelial cell lines.

引用

页码：3623 / 3626

页数：4

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