Antitumor agents 201.: Cytotoxicity of harmine and β-carboline analogs

被引：159
作者：
Ishida, J
Wang, HK
Bastow, KF
Hu, CQ
Lee, KH [1 ]
机构：
[1] Univ N Carolina, Sch Pharm, Nat Prod Lab, Chapel Hill, NC 27599 USA
[2] Univ N Carolina, Sch Pharm, Div Med Chem & Nat Prod, Chapel Hill, NC 27599 USA
[3] Shanghai Med Univ, Sch Pharm, Shanghai 200032, Peoples R China
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1999年 / 9卷 / 23期
关键词：
D O I：
10.1016/S0960-894X(99)00598-3
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Twenty-six beta-carbolines were evaluated for in vitro cytotoxicity in a human tumor cell line panel. Harmine (3) showed significant activity against several cell lines including three drug-resistant KB sublines with various resistance mechanisms. alpha-(4-Nitrobenzylidine) harmine (16) had a broad cytotoxicity spectrum (ED50 values from 0.3-1.2 mu g/mL against 1A9, KB, SaOS-2, A549, SK-MEL-2, U-87-MG, and MCF-7 cells). (C) 1999 Published by Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：3319 / 3324
页数：6
相关论文
共 8 条
[1]  
Beidler DR, 1996, CANCER RES, V56, P345
[2]   1-AMINO-SUBSTITUTED 4-METHYL-5H-PYRIDO[4,3-B]INDOLES (GAMMA-CARBOLINES) AS TRICYCLIC ANALOGS OF ELLIPTICINES - A NEW CLASS OF ANTINEOPLASTIC AGENTS [J].
BISAGNI, E ;
NGUYEN, CH ;
PIERRE, A ;
PEPIN, O ;
DECOINTET, P ;
GROS, P .
JOURNAL OF MEDICINAL CHEMISTRY, 1988, 31 (02) :398-405
[3]   GENOTOXIC POTENTIAL OF BETA-CARBOLINES - A REVIEW [J].
DEMEESTER, C .
MUTATION RESEARCH-REVIEWS IN GENETIC TOXICOLOGY, 1995, 339 (03) :139-153
[4]  
FERGUSON PJ, 1988, CANCER RES, V48, P5956
[5]   Effects of beta- and gamma-carboline derivatives on DNA topoisomerase activities [J].
Funayama, Y ;
Nishio, K ;
Wakabayashi, K ;
Nagao, M ;
Shimoi, K ;
Ohira, T ;
Hasegawa, S ;
Saijo, N .
MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS, 1996, 349 (02) :183-191
[6]   Antitumor agents 200. Cytotoxicity of naturally occurring resveratrol oligomers and their acetate derivatives [J].
Ohyama, M ;
Tanaka, T ;
Ito, T ;
Iinuma, M ;
Bastow, KF ;
Lee, KH .
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1999, 9 (20) :3057-3060
[7]   COMPARISON OF INVITRO ANTICANCER-DRUG-SCREENING DATA GENERATED WITH A TETRAZOLIUM ASSAY VERSUS A PROTEIN ASSAY AGAINST A DIVERSE PANEL OF HUMAN TUMOR-CELL LINES [J].
RUBINSTEIN, LV ;
SHOEMAKER, RH ;
PAULL, KD ;
SIMON, RM ;
TOSINI, S ;
SKEHAN, P ;
SCUDIERO, DA ;
MONKS, A ;
BOYD, MR .
JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1990, 82 (13) :1113-1118
[8]  
SPATH E, 1920, MONATSH, V41, P401
1