Antitumor agents 201.: Cytotoxicity of harmine and β-carboline analogs

被引：158
|
作者：
Ishida, J
Wang, HK
Bastow, KF
Hu, CQ
Lee, KH [1 ]
机构：
[1] Univ N Carolina, Sch Pharm, Nat Prod Lab, Chapel Hill, NC 27599 USA
[2] Univ N Carolina, Sch Pharm, Div Med Chem & Nat Prod, Chapel Hill, NC 27599 USA
[3] Shanghai Med Univ, Sch Pharm, Shanghai 200032, Peoples R China
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1999年 / 9卷 / 23期
关键词：
D O I：
10.1016/S0960-894X(99)00598-3
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Twenty-six beta-carbolines were evaluated for in vitro cytotoxicity in a human tumor cell line panel. Harmine (3) showed significant activity against several cell lines including three drug-resistant KB sublines with various resistance mechanisms. alpha-(4-Nitrobenzylidine) harmine (16) had a broad cytotoxicity spectrum (ED50 values from 0.3-1.2 mu g/mL against 1A9, KB, SaOS-2, A549, SK-MEL-2, U-87-MG, and MCF-7 cells). (C) 1999 Published by Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：3319 / 3324
页数：6
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