New and Emerging Therapies in Psoriasis

被引：0

作者：

Leonardi, Craig L. ^{[1
,2
]}

Gordon, Kenneth B. ^{[3
]}

机构：

[1] St Louis Univ, St Louis, MO 63103 USA

[2] Cent Dermatol, St Louis, MO 63117 USA

[3] Northwestern Univ, Feinberg Sch Med, Chicago, IL USA

来源：

SEMINARS IN CUTANEOUS MEDICINE AND SURGERY | 2014年 / 33卷

关键词：

Apremilast; brodalumab; interleukin-12/23; inhibitors; interleukin-17; ixekizumab; JAK; Janus kinase inhibitors; phosphodiesterase-4; psoriasis treatment; secukinumab; tildrakizumab; tofacitinib; tumor necrosis factor inhibitors; ustekinumab; INTERLEUKIN-12/23; MONOCLONAL-ANTIBODY; CHRONIC PLAQUE PSORIASIS; TO-SEVERE PSORIASIS; DOUBLE-BLIND; USTEKINUMAB; SAFETY; EFFICACY; TRIAL;

D O I：

暂无

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

This article discusses the scientific rationale for the use of cytokine inhibitors, including ustekinumab, an inhibitor of the interleukin (IL)-12 and IL-23 pathways in psoriasis. Also addressed are the efficacy and safety data for this agent, as well as for several emerging therapies that target other cytokine pathways in psoriasis: the IL-17 inhibitors secukinumab, ixekizumab, and brodalumab, the IL-23 blacker tildrakizumab, and the small-molecule kinase inhibitors apremilast (a phosphodiesterase-4 blacker) and tofacitinib (a Janus kinase inhibitor). (C) 2014 published by Frontline Medical Communications

引用

页码：S37 / S41

页数：5

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