Simultaneous Kinase Inhibition with Ibrutinib and BCL2 Inhibition with Venetoclax As a Therapeutic Strategy for Acute Lymphoblastic Leukemia

被引:0
|
作者
Eide, Christopher A. [1 ,2 ]
Kurtz, Stephen E. [1 ]
Kaempf, Andy [3 ]
Long, Nicola [1 ]
Leonard, Jessica [1 ]
Chang, Bill H. [4 ]
Mori, Motomi [3 ,5 ]
Druker, Brian J. [1 ,2 ]
Tyner, Jeffrey W. [1 ,6 ]
机构
[1] Oregon Hlth & Sci Univ, Knight Canc Inst, Div Hematol & Med Oncol, Portland, OR 97201 USA
[2] Howard Hughes Med Inst, Portland, OR USA
[3] Oregon Hlth & Sci Univ, Knight Canc Inst, Biostat Shared Resource, Portland, OR 97201 USA
[4] Oregon Hlth & Sci Univ, Knight Canc Inst, Div Pediat Hematol & Oncol, Portland, OR 97201 USA
[5] Oregon Hlth & Sci Univ, Sch Publ Hlth, Portland State Univ, Portland, OR 97201 USA
[6] Oregon Hlth & Sci Univ, Dept Cell Dev & Canc Biol, Portland, OR 97201 USA
关键词
D O I
10.1182/blood-2019-131288
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
3950
引用
收藏
页数:4
相关论文
共 50 条
  • [31] The BCL2 rheostat in glucocorticoid-induced apoptosis of acute lymphoblastic leukemia
    Ploner, C.
    Rainer, J.
    Niederegger, H.
    Eduardoff, M.
    Villunger, A.
    Geley, S.
    Kofler, R.
    LEUKEMIA, 2008, 22 (02) : 370 - 377
  • [32] Targeting BET proteins improves the therapeutic efficacy of BCL-2 inhibition in T-cell acute lymphoblastic leukemia
    Peirs, S.
    Frismantas, V.
    Matthijssens, F.
    Van Loocke, W.
    Pieters, T.
    Vandamme, N.
    Lintermans, B.
    Dobay, M. P.
    Berx, G.
    Poppe, B.
    Goossens, S.
    Bornhauser, B. C.
    Bourquin, J-P
    Van Vlierberghe, P.
    LEUKEMIA, 2017, 31 (10) : 2037 - 2047
  • [33] The BCL2 rheostat in glucocorticoid-induced apoptosis of acute lymphoblastic leukemia
    C Ploner
    J Rainer
    H Niederegger
    M Eduardoff
    A Villunger
    S Geley
    R Kofler
    Leukemia, 2008, 22 : 370 - 377
  • [34] Targeting BET proteins improves the therapeutic efficacy of BCL-2 inhibition in T-cell acute lymphoblastic leukemia
    S Peirs
    V Frismantas
    F Matthijssens
    W Van Loocke
    T Pieters
    N Vandamme
    B Lintermans
    M P Dobay
    G Berx
    B Poppe
    S Goossens
    B C Bornhauser
    J-P Bourquin
    P Van Vlierberghe
    Leukemia, 2017, 31 : 2037 - 2047
  • [35] RBP2 Promotes Adult Acute Lymphoblastic Leukemia by Upregulating BCL2
    Wang, Xiaoming
    Zhou, Minran
    Fu, Yue
    Sun, Ting
    Chen, Jin
    Qin, Xuemei
    Yu, Yuan
    Jia, Jihui
    Chen, Chunyan
    PLOS ONE, 2016, 11 (03):
  • [36] Genetic or pharmacological inactivation of CREBBP sensitizes B-cell acute lymphoblastic leukemia to ferroptotic cell death upon BCL2 inhibition
    Gimenez, Alicia Garcia
    Ditcham, Jonathan
    Azazi, Dhoyazan M.
    Meduri, Eshwar
    Asby, Ryan
    Sakakini, Nathalie
    Lopez, Cecile K.
    Narayan, Nisha
    Bagri, Jaana
    Beinortas, Tumas
    Singh, Shuchi Agrawal
    Giotopoulos, George
    Murphy, Michael P.
    Horton, Sarah J.
    Huntly, Brian J.
    Richardson, Simon E.
    CANCER RESEARCH, 2024, 84 (06)
  • [37] The Inhibition of Checkpoint Kinase 1 As a Promising Strategy to Increase the Effectiveness of Different Treatments in Acute Lymphoblastic Leukemia
    Di Rora, Andrea Ghelli Luserna
    Iacobucci, Ilaria
    Imbrogno, Enrica
    Derenzini, Enrico
    Ferrari, Anna
    Guadagnuolo, Viviana
    Robustelli, Valentina
    Soverini, Simona
    Papayannidis, Cristina
    Abbenante, Maria Chiara
    Cavo, Michele
    Martinelli, Giovanni
    BLOOD, 2015, 126 (23)
  • [38] Synergistic effect of BCL2 and FLT3 co-inhibition in acute myeloid leukemia
    Lindsey T. Brinton
    Pu Zhang
    Katie Williams
    Daniel Canfield
    Shelley Orwick
    Steven Sher
    Ronni Wasmuth
    Larry Beaver
    Casey Cempre
    Jordan Skinner
    Matthew Cannon
    Mukul Govande
    Bonnie Harrington
    Amy Lehman
    John C. Byrd
    Rosa Lapalombella
    James S. Blachly
    Journal of Hematology & Oncology, 13
  • [39] Synergistic effect of BCL2 and FLT3 co-inhibition in acute myeloid leukemia
    Brinton, Lindsey T.
    Zhang, Pu
    Williams, Katie
    Canfield, Daniel
    Orwick, Shelley
    Sher, Steven
    Wasmuth, Ronni
    Beaver, Larry
    Cempre, Casey
    Skinner, Jordan
    Cannon, Matthew
    Govande, Mukul
    Harrington, Bonnie
    Lehman, Amy
    Byrd, John C.
    Lapalombella, Rosa
    Blachly, James S.
    JOURNAL OF HEMATOLOGY & ONCOLOGY, 2020, 13 (01)
  • [40] Inhibition of mTOR kinase as a therapeutic target for acute myeloid leukemia
    Tabe, Yoko
    Tafuri, Agostino
    Sekihara, Kazumasa
    Yang, Haeun
    Konopleva, Marina
    EXPERT OPINION ON THERAPEUTIC TARGETS, 2017, 21 (07) : 705 - 714