Clinical significance of the number of oligoclonal bands in patients with clinically isolated syndromes

被引：15
|
作者：
Costa, Gloria Dalla [1 ]
Passerini, Gabriella [2 ]
Messina, Maria Jose [1 ]
Moiola, Lucia [1 ]
Rodegher, Mariaemma [1 ]
Colombo, Bruno [1 ]
Locatelli, Massimo [2 ]
Comi, Giancarlo [1 ]
Furlan, Roberto [3 ]
Martinelli, Vittorio [1 ]
机构：
[1] Hosp San Raffaele, Dept Neurol, I-20132 Milan, Italy
[2] Hosp San Raffaele, Dept Lab Med, I-20132 Milan, Italy
[3] Inst Expt Neurol, Neuroimmunol Res Unit, Milan, Italy
来源：
JOURNAL OF NEUROIMMUNOLOGY | 2015年 / 289卷
关键词：
Multiple sclerosis; Oligoclonal bands; Cerebrospinal fluid; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; CEREBROSPINAL-FLUID ANALYSIS; MULTIPLE-SCLEROSIS; FOLLOW-UP; CSF; DISABILITY; PROGNOSIS; MODELS; MRI; PROGRESSION;
D O I：
10.1016/j.jneuroim.2015.10.009
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
CSF oligoclonal bands (OCBs) in patients with clinically isolated syndromes (CIS) are a risk factor for clinically definite multiple sclerosis (CDMS). We aimed to address the relevance of the number of OCBs in the prognosis of CIS patients. 219 CIS patients were included in the study, and 42% of them developed the disease during follow-up (median: 5.04 years). Patients with a high number of CSF OCBs (third quartile, 8-12 OCBs) had 2.5-fold increase in CDMS risk, while no further increase in the HR of disease was observed for patients with more than 12 OCBs. The results did not change after adjustment for additional correlates of CDMS development. This association may be due to the epitope-spreading phenomenon and may reflect the stage of the disease at the time of the examination. (C) 2015 Elsevier B.V. All rights reserved.
引用
收藏
页码：62 / 67
页数：6
相关论文
共 50 条
  • [31] Clinically isolated syndromes
    Miller, David H.
    Chard, Declan T.
    Ciccarelli, Olga
    LANCET NEUROLOGY, 2012, 11 (02): : 157 - 169
  • [32] Presence of CSF oligoclonal bands is associated with periventricular NAWM damage gradient severity in clinically isolated syndrome
    Pardini, M.
    Gualco, L.
    Bommarito, G.
    Roccatagliata, L.
    Laroni, A.
    Solaro, C.
    Uccelli, A.
    Capello, E.
    Inglese, M.
    MULTIPLE SCLEROSIS JOURNAL, 2018, 24 : 204 - 205
  • [33] Relevance of the study of oligoclonal bands as a prognostic factor of the conversion of clinically isolated syndrome into clinically definite multiple sclerosis in daily practice
    Dionet, Elsa
    Taithe, Frederic
    Lauxerois, Michel
    Fogli, Anne
    Clavelou, Pierre
    MULTIPLE SCLEROSIS, 2008, 14 : S119 - S119
  • [34] Change in number and pattern of CSF oligoclonal bands in MS patients over time
    Axelsson, M.
    Mattsson, N.
    Malmestrom, C.
    Nilsson, S.
    Haghighi, S.
    Rosengren, L.
    Zetterberg, H.
    Lycke, J.
    MULTIPLE SCLEROSIS JOURNAL, 2011, 17 : S281 - S282
  • [35] Cognitive impairment predicts the clinical conversion to multiple sclerosis in patients with clinically isolated syndromes
    Zipoli, V.
    Goretti, B.
    Portaccio, E.
    Amato, M. P.
    JOURNAL OF NEUROLOGY, 2009, 256 : S161 - S161
  • [36] Cognitive Impairment Predicts the Clinical Conversion to Multiple Sclerosis in Patients with Clinically Isolated Syndromes
    Zipoli, Valentina
    Goretti, Benedetta
    Portaccio, Emilio
    Amato, Maria Pia
    NEUROLOGY, 2009, 72 (11) : A409 - A409
  • [37] The significance of oligoclonal bands in multiple sclerosis: Relevance of demographic and clinical features, and immunogenetic backgrounds
    Idiman, Egemen
    Ozakbas, Serkan
    Dogan, Yavuz
    Kosehasanogullari, Gorkem
    JOURNAL OF NEUROIMMUNOLOGY, 2009, 212 (1-2) : 121 - 124
  • [38] Cognitive impairment predicts the clinical conversion to multiple sclerosis in patients with clinically isolated syndromes
    Zipoli, V.
    Goretti, B.
    Portaccio, E.
    Hakiki, B.
    Siracusa, G.
    Sorbi, S.
    Amato, M. P.
    EUROPEAN JOURNAL OF NEUROLOGY, 2009, 16 : 265 - 265
  • [39] Cerebrospinal fluid CXCL13 in clinically isolated syndrome patients: Association with oligoclonal IgM bands and prediction of Multiple Sclerosis diagnosis
    Ferraro, Diana
    Galli, Veronica
    Vitetta, Francesca
    Simone, Anna Maria
    Bedin, Roberta
    Del Giovane, Cinzia
    Morselli, Franca
    Filippini, Maria Maddalena
    Nichelli, Paolo Frigio
    Sola, Patrizia
    JOURNAL OF NEUROIMMUNOLOGY, 2015, 283 : 64 - 69
  • [40] MRI criteria for MS in patients with clinically isolated syndromes
    Montalban, X.
    Tintore, M.
    Swanton, J.
    Barkhof, F.
    Fazekas, F.
    Filippi, M.
    Frederiksen, J.
    Kappos, L.
    Palace, J.
    Polman, C.
    Rovaris, M.
    de Stefano, N.
    Thompson, A.
    Yousry, T.
    Rovira, A.
    Miller, D. H.
    NEUROLOGY, 2010, 74 (05) : 427 - 434
12345