Clinical significance of the number of oligoclonal bands in patients with clinically isolated syndromes

被引：15
|
作者：
Costa, Gloria Dalla [1 ]
Passerini, Gabriella [2 ]
Messina, Maria Jose [1 ]
Moiola, Lucia [1 ]
Rodegher, Mariaemma [1 ]
Colombo, Bruno [1 ]
Locatelli, Massimo [2 ]
Comi, Giancarlo [1 ]
Furlan, Roberto [3 ]
Martinelli, Vittorio [1 ]
机构：
[1] Hosp San Raffaele, Dept Neurol, I-20132 Milan, Italy
[2] Hosp San Raffaele, Dept Lab Med, I-20132 Milan, Italy
[3] Inst Expt Neurol, Neuroimmunol Res Unit, Milan, Italy
来源：
JOURNAL OF NEUROIMMUNOLOGY | 2015年 / 289卷
关键词：
Multiple sclerosis; Oligoclonal bands; Cerebrospinal fluid; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; CEREBROSPINAL-FLUID ANALYSIS; MULTIPLE-SCLEROSIS; FOLLOW-UP; CSF; DISABILITY; PROGNOSIS; MODELS; MRI; PROGRESSION;
D O I：
10.1016/j.jneuroim.2015.10.009
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
CSF oligoclonal bands (OCBs) in patients with clinically isolated syndromes (CIS) are a risk factor for clinically definite multiple sclerosis (CDMS). We aimed to address the relevance of the number of OCBs in the prognosis of CIS patients. 219 CIS patients were included in the study, and 42% of them developed the disease during follow-up (median: 5.04 years). Patients with a high number of CSF OCBs (third quartile, 8-12 OCBs) had 2.5-fold increase in CDMS risk, while no further increase in the HR of disease was observed for patients with more than 12 OCBs. The results did not change after adjustment for additional correlates of CDMS development. This association may be due to the epitope-spreading phenomenon and may reflect the stage of the disease at the time of the examination. (C) 2015 Elsevier B.V. All rights reserved.
引用
收藏
页码：62 / 67
页数：6
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