Pathogenic memory type Th2 cells in allergic inflammation

被引：104

作者：

Endo, Yusuke ^{[1
]}

Hirahara, Kiyoshi ^{[2
]}

Yagi, Ryoji ^{[1
]}

Tumes, Damon J. ^{[1
]}

Nakayama, Toshinori ^{[1
,3
]}

机构：

[1] Chiba Univ, Grad Sch Med, Dept Immunol, Chuo Ku, Chiba 2608670, Japan

[2] Chiba Univ, Grad Sch Med, Dept Adv Allergol Airway, Chuo Ku, Chiba 2608670, Japan

[3] Japan Sci & Technol Agcy JST, CREST, Chuo Ku, Chiba 2608670, Japan

来源：

TRENDS IN IMMUNOLOGY | 2014年 / 35卷 / 02期

关键词：

INNATE LYMPHOID-CELLS; TRANSCRIPTION FACTOR GATA3; EFFECTOR T-CELLS; AIRWAY INFLAMMATION; IMMUNE-RESPONSES; T(H)2 CELLS; CYTOKINE PRODUCTION; ATOPIC-DERMATITIS; DENDRITIC CELLS; MOUSE MODEL;

D O I：

10.1016/j.it.2013.11.003

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Immunological memory is a hallmark of adaptive immunity. Memory CD4 T helper (Th) cells are central to acquired immunity, and vaccines for infectious diseases are developed based on this concept. However, memory Th cells also play a critical role in the pathogenesis of various chronic inflammatory diseases, including asthma. We refer to these populations as 'pathogenic memory Th cells.' Here, we review recent developments highlighting the functions and characteristics of several pathogenic memory type Th2 cell subsets in allergic inflammation. Also discussed are the similarities and differences between pathogenic memory Th2 cells and recently identified type 2 innate lymphoid cells (ILC2), focusing on cytokine production and phenotypic profiles.

引用

收藏

页码：69 / 78

页数：10

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