X-Irradiation at 0.5 Gy after the forced swim test reduces forced swimming-induced immobility in mice

被引：8

作者：

Kataoka, Takahiro ^{[1
]}

Shuto, Hina ^{[1
]}

Yano, Junki ^{[1
]}

Naoe, Shota ^{[1
]}

Ishida, Tsuyoshi ^{[1
]}

Nakada, Tetsuya ^{[1
]}

Yamato, Keiko ^{[2
]}

Hanamoto, Katsumi ^{[1
]}

Nomura, Takaharu ^{[3
]}

Yamaoka, Kiyonori ^{[1
]}

机构：

[1] Okayama Univ, Grad Sch Hlth Sci, Kita Ku, 5-1 Shikata Cho 2 Chome, Okayama, Okayama 7008558, Japan

[2] Natl Cerebral & Cardiovasc Ctr, Lab Neurol & Neurosurg, 5-7-1 Fujishiro Dai, Suita, Osaka 5658565, Japan

[3] Cent Res Inst Elect Power Ind, 2-11-1 Iwadokita, Komae, Tokyo 2018511, Japan

来源：

JOURNAL OF RADIATION RESEARCH | 2020年 / 61卷 / 04期

关键词：

X-irradiation; forced swim test; antioxidants; brain; oxidative stress; DOSE GAMMA-RAYS; OXIDATIVE STRESS; RADON; GLUTATHIONE; DEPRESSION; ELEVATION; PEROXIDE; ISCHEMIA; PROTECTS; INJURY;

D O I：

10.1093/jrr/rraa022

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The forced swim test (FST) is a screening model for antidepressant activity; it causes immobility and induces oxidative stress. We previously reported that radon inhalation has antidepressant-like effects in mice potentially through the activation of antioxidative functions upon radon inhalation. This study aimed to investigate the effect of prior and post low-dose X-irradiation (0.1, 0.5, 1.0 and 2.0 Gy) on FST-induced immobility and oxidative stress in the mouse brain, and the differences, if any, between the two. Mice received X-irradiation before or after the FST repeatedly for 5 days. In the post-FST-irradiated group, an additional FST was conducted 4h after the last irradiation. Consequently, animals receiving prior X-irradiation (0.1 Gy) had better mobility outcomes than sham-irradiated mice; however, their levels of lipid peroxide (LPO), an oxidative stress marker, remained unchanged. However, animals that received post-FST X-irradiation (0.5 Gy) had better mobility outcomes and their LPO levels were significantly lower than those of the sham-irradiated mice. The present results indicate that 0.5 Gy X-irradiation after FST inhibits FST-induced immobility and oxidative stress in mice.

引用

页码：517 / 523

页数：7

共 31 条

[1] NF-κB-mediated adaptive resistance to ionizing radiation [J].