The novel Bruton's tyrosine kinase inhibitor ARQ531 disrupts survival signaling and triggers apoptosis in AML cells

被引:0
|
作者
Debora, Soncini [1 ]
Orecchioni, Stefania [2 ]
Cagnetta, Antonia [1 ]
Retali, Veronica [1 ]
Ruberti, Samantha [1 ]
Minetto, Paola [1 ]
Contini, Paola [1 ]
Nencioni, Alessio [1 ]
Monacelli, Fiammetta [1 ]
Hall, Terence [3 ]
Gobbi, Marco [1 ]
Eathiraj, Sudharshan [3 ]
Schwartz, Briam [3 ]
Bertolini, Francesco [2 ]
Lemoli, Roberto [1 ]
Cea, Michele [1 ]
机构
[1] Univ Genoa, Genoa, Italy
[2] European Inst Oncol, Milan, Italy
[3] ARQULE, Burlington, MA USA
关键词
D O I
10.1158/1538-7445.AM2018-793
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
793
引用
收藏
页数:2
相关论文
共 50 条
  • [21] Bruton's tyrosine kinase as an inhibitor of the Fas/CD95 death-inducing signaling complex
    Vassilev, A
    Ozer, Z
    Navara, C
    Mahajan, S
    Uckun, FM
    JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (03) : 1646 - 1656
  • [22] Ibrutinib: a novel Bruton's tyrosine kinase inhibitor with outstanding responses in patients with chronic lymphocytic leukemia
    Barrientos, Jacqueline
    Rai, Kanti
    LEUKEMIA & LYMPHOMA, 2013, 54 (08) : 1817 - 1820
  • [23] Bruton's tyrosine kinase regulates apoptosis and JNK1/SAPK kinase activity in mast cells.
    Kawakami, Y
    Hata, D
    Hartman, SE
    Yao, L
    Kawakami, T
    JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 1997, 99 (01) : 387 - 387
  • [24] Bruton's tyrosine kinase (BTK) as an inhibitor of the FAS/CD95 death inducing signaling complex (DISC).
    Vassilev, A
    Ozer, Z
    Navara, C
    Ghosh, S
    Zheng, Y
    Mahajan, S
    Uckun, FM
    BLOOD, 1998, 92 (10) : 601A - 601A
  • [25] Discovery of Zanubrutinib (BGB-3111), a Novel, Potent, and Selective Covalent Inhibitor of Bruton's Tyrosine Kinase
    Guo, Yunhang
    Liu, Ye
    Hu, Nan
    Yu, Desheng
    Zhou, Changyou
    Shi, Gongyin
    Zhang, Bo
    Wei, Min
    Liu, Junhua
    Luo, Lusong
    Tang, Zhiyu
    Song, Huipeng
    Guo, Yin
    Liu, Xuesong
    Su, Dan
    Zhang, Shuo
    Song, Xiaomin
    Zhou, Xing
    Hong, Yuan
    Chen, Shuaishuai
    Cheng, Zhenzhen
    Young, Steve
    Wei, Qiang
    Wang, Haisheng
    Wang, Qiuwen
    Lv, Lei
    Wang, Fan
    Xu, Haipeng
    Sun, Hanzi
    Xing, Haimei
    Li, Na
    Zhang, Wei
    Wang, Zhongbo
    Liu, Guodong
    Sun, Zhijian
    Zhou, Dongping
    Li, Wei
    Liu, Libin
    Wang, Lai
    Wang, Zhiwei
    JOURNAL OF MEDICINAL CHEMISTRY, 2019, 62 (17) : 7923 - 7940
  • [26] Bruton's tyrosine kinase (BTK) inhibits constitutive neutrophil (PMN) apoptosis and prolongs PMN survival in sepsis.
    Keen, J
    Parodo, J
    Jia, S
    Marshall, JC
    SHOCK, 2004, 21 : 73 - 73
  • [27] Pleiotropic Action of Novel Bruton's Tyrosine Kinase Inhibitor BGB-3111 in Mantle Cell Lymphoma
    Li, Carrie J.
    Jiang, Changying
    Liu, Yang
    Bell, Taylor
    Ye, Yin
    Huang, Shengjian
    Guo, Hui
    Zhang, Hui
    Wang, Lai
    Wang, Jing
    Nomie, Krystle
    Zhang, Liang
    Wang, Michael
    Ma, Wencai
    MOLECULAR CANCER THERAPEUTICS, 2019, 18 (02) : 267 - 277
  • [28] SILENCING OF BRUTON'S TYROSINE KINASE BY RNA INTERFERENCE INDUCES APOPTOSIS IN PRIMARY CHRONIC LYMPHOCYTIC LEUKEMIA CELLS
    Bojnik, E.
    Autore, F.
    Laurenti, L.
    Efremov, D.
    HAEMATOLOGICA, 2013, 98 : 217 - 217
  • [29] Bruton Tyrosine Kinase Inhibitor Suppresses Inflammatory Profile of Human T Cells; a Novel Immunomodulatory Mechanism in Treatment of Neuroinflammation
    Safavi, Farinaz
    Calco, Brice
    Nath, Avindra
    ANNALS OF NEUROLOGY, 2022, 92 : S176 - S177
  • [30] Novel Bruton's Tyrosine Kinase Inhibitor Bgb-3111 Demonstrates Potent Activity in Mantle Cell Lymphoma
    Li, Carrie J.
    Liu, Yang
    Bell, Taylor
    Wang, Jack
    Guo, Hui
    Ahmed, Makhdum
    Zhang, Hui
    Lam, Laura T.
    Nomie, Krystle
    Wang, Lai
    Zhang, Liang
    Wang, Michael
    BLOOD, 2016, 128 (22)