TiO2 Printed Aluminum Foil: Single-Use Film for a Laser Desorption/Ionization Target Plate

被引：43

作者：

Bi, Hongyan ^{[2
]}

Qiao, Liang ^{[1
]}

Busnel, Jean-Marc ^{[2
]}

Devaud, Valerie ^{[2
]}

Liu, Baohong ^{[1
]}

Girault, Hubert H. ^{[2
]}

机构：

[1] Fudan Univ, Dept Chem, Inst Biomed Sci, Shanghai 200433, Peoples R China

[2] Ecole Polytech Fed Lausanne, Lab Electrochim Phys & Analyt, Stn 6, CH-1015 Lausanne, Switzerland

来源：

ANALYTICAL CHEMISTRY | 2009年 / 81卷 / 03期

基金：

瑞士国家科学基金会;

关键词：

MASS-SPECTROMETRY; PHOSPHORYLATED PEPTIDES; ENRICHMENT; PROTEINS; SURFACE; PHOSPHOPEPTIDES; MS; PHOTOCATALYSIS; MATRIX;

D O I：

10.1021/ac8024448

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Single-use aluminum foil-based laser desorption/ionization (LDI) target plates have been developed for mass spectrometry (MS) analysis and provide detection results comparable to those of commercial stainless steel plates while offering a convenient way to avoid the time-consuming surface cleaning process. Additionally, arrays of TiO2 nanoparticle spots are coated on the foil either by screen-printing or rotogravure-printing followed by sintering to form a mesoporous layer spot to act as an anchor for sample deposition. These TiO2 spots offer further functions to the Al foil, such as matrix-free laser desorption/ionization or specific affinity for in situ enrichment of phosphopeptides. The single-use TiO2-Al foils are cheap to produce, easy to use, and well suited for high-throughput proteomics research. They can also be of interest for protein post-translational modifications study.

引用

页码：1177 / 1183

页数：7

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