The Mre11 complex: At the crossroads of DNA repair and checkpoint signalling

被引：687
作者：
D'Amours, D
Jackson, SP
机构：
[1] Univ Cambridge, Wellcome Trust & Canc Res UK Inst Canc & Dev Biol, Cambridge CB2 1QR, England
[2] Univ Cambridge, Dept Zool, Cambridge CB2 1QR, England
来源：
NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2002年 / 3卷 / 05期
关键词：
D O I：
10.1038/nrm805
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The Mre11 complex is a multisubunit nuclease that is composed of Mre11, Rad50 and Nbs1/Xrs2. Mutations in the genes that encode components of this complex result in DNA-damage sensitivity, genomic instability, telomere shortening and aberrant meiosis. The molecular defect that underlies these phenotypes has long been thought to be related to a DNA repair deficiency. However, recent studies have uncovered functions for the Mre11 complex in checkpoint signalling and DNA replication.
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页码：317 / 327
页数：11
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