Primary Alveolar Soft Part Sarcoma of Cheek: Report of a Case and Review of the Literature

被引：3

作者：

Hirose, Katsutoshi ^{[1
]}

Naniwa, Kohei ^{[1
]}

Usami, Yu ^{[1
]}

Kohara, Masaharu ^{[2
]}

Uchihashi, Toshihiro ^{[3
,4
]}

Tanaka, Susumu ^{[3
]}

Yamada, Saori ^{[3
]}

Iwamoto, Yuri ^{[5
]}

Murakami, Shumei ^{[5
]}

Oya, Kaori ^{[6
]}

Fukuda, Yasuo ^{[6
]}

Hori, Yumiko ^{[2
]}

Morii, Eiichi ^{[2
]}

Toyosawa, Satoru ^{[1
]}

机构：

[1] Osaka Univ, Dept Oral Pathol, Grad Sch Dent, 1-8 Yamadaoka, Suita, Osaka 5650871, Japan

[2] Osaka Univ, Dept Pathol, Grad Sch Med, 2-2 Yamadaoka, Suita, Osaka 5650871, Japan

[3] Osaka Univ, Dept Oral & Maxillofacial Surg 1, Grad Sch Dent, 1-8 Yamadaoka, Suita, Osaka 5650871, Japan

[4] Osaka Univ Hosp, Unit Dent, 2-15 Yamadaoka, Suita, Osaka 5650871, Japan

[5] Osaka Univ, Dept Oral & Maxillofacial Radiol, Grad Sch Dent, 1-8 Yamadaoka, Suita, Osaka 5650871, Japan

[6] Osaka Univ, Clin Lab, Dent Hosp, 1-8 Yamadaoka, Suita, Osaka 5650871, Japan

来源：

HEAD & NECK PATHOLOGY | 2021年 / 15卷 / 04期

关键词：

Alveolar soft part sarcoma; ASPS; Cheek tumour; ASPSCR1; TFE3;

D O I：

10.1007/s12105-021-01324-6

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Alveolar soft part sarcoma (ASPS) is a rare soft tissue sarcoma characterized by an alveolar or organoid arrangement of polygonal tumour cells separated by fibrovascular septa. A specific fusion gene [ASPS critical region 1 (ASPSCR1)-TFE3] was detected in ASPS. Despite being a slow-growing tumour without pain and dysfunction, ASPS is characterized by early metastasis, which leads to poor prognosis. Herein, we report a rare case of primary ASPS of the cheek harbouring ASPSCR1 (exon 7)-TFE3 (exon 5) fusion gene in a 21 year-old woman. This tumour was a well-circumscribed, smooth, round mass that was clinically suspected as a benign tumour. However, histologically, it was observed that the polygonal tumour cells were arranged in solid and alveolar growth patterns. Post-operative examination of the whole body excluded the possibility of metastasis at other sites. Thus, careful immunohistochemical and genetic analyses, as well as whole-body examination, demonstrated that the tumour was a primary ASPS of the cheek.

引用

页码：1426 / 1431

页数：6