Cathepsin D concentration in tumor cytosols improves the accuracy of prognostic evaluation of primary breast cancer

被引：0

作者：

Ardavanis, A

Scorilas, A

Amanatidou, A

Gerakini, F

Missitzis, I

Garoufali, A

Pissakas, G

Pateras, C

Apostolikas, N

Rigatos, G

Yiotis, I

机构：

[1] ST SAVVAS CANC HOSP,HORMONAL RECEPTORS LAB,ATHENS 11522,GREECE

[2] ST SAVVAS CANC HOSP,BREAST CLIN,ATHENS 11522,GREECE

[3] ST SAVVAS CANC HOSP,RADIOTHERAPY DEPT 2,ATHENS 11522,GREECE

[4] ST SAVVAS CANC HOSP,PATHOL LAB,ATHENS 11522,GREECE

来源：

ANTICANCER RESEARCH | 1997年 / 17卷 / 2B期

关键词：

breast cancer; prognostic factors; cathepsin D;

D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

One hundred and seventy three women were followed-up for a median of 62 months after surgery for Stage I-III breast cancer: The concentration of cathepsin D (CD) in tumor cytosols was compared to the standard prognostic factors for the disease and related to relapse free and overall survival and type of relapse. Three groups were identified with different prognostic profile. High CD levels significantly shorten DFS ill both node-negative and node-positive patients; a correlation between high cathepsin D levels and locoregional relapse should also be noted. This marker should be included in the initial evaluation of breast cancer as an indicator of invasiveness.

引用

页码：1405 / 1409

页数：5

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