Animal models of smoke inhalation induced injuries

被引：20

作者：

David, Poon ^{[1
]}

Dunsford, Denny ^{[1
]}

Lu, Jia ^{[1
]}

Moochhala, Shabbir ^{[1
]}

机构：

[1] Def Med & Environm Res Inst, DSO Natl Labs Kent Ridge, Combat Care & Performance Programme, Combat Care Lab, Singapore 117510, Singapore

来源：

FRONTIERS IN BIOSCIENCE-LANDMARK | 2009年 / 14卷

关键词：

Smoke inhalation; Acute lung injury; Animal models; Pathophysiology; Treatment; Therapeutics; Review; ACUTE LUNG INJURY; MANGANESE SUPEROXIDE-DISMUTASE; POSITIVE PRESSURE VENTILATION; COMBINED BURN; VITAMIN-E; NITRIC-OXIDE; PULMONARY-FUNCTION; CARBOXYETHYL-HYDROXYCHROMAN; BRONCHIAL CIRCULATION; CIGARETTE SMOKERS;

D O I：

10.2741/3554

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Smoke inhalation injury is the leading cause of mortality from structural fires, as a result of complications such as systemic inflammatory response syndrome and chronic obstructive pulmonary disease, which can be caused by a localized or systemic response. In this review, the pathophysiology of smoke inhalation injury, along with the characteristics found in clinical settings, common animal models, current treatment methods and future potential therapeutics are discussed.

引用

页码：4618 / 4630

页数：13

共 108 条

[61] Pathophysiological basis of smoke inhalation injury [J].

Murakami, K ;

Traber, DL .

NEWS IN PHYSIOLOGICAL SCIENCES, 2003, 18 :125-129

[62] High-dose heparin fails to improve acute lung injury following smoke inhalation in sheep [J].

Murakami, K ;

Enkhbaatar, P ;

Shimoda, K ;

Mizutani, A ;

Cox, RA ;

Schmalstieg, FC ;

Jodoin, JM ;

Hawkins, HK ;

Traber, LD ;

Traber, DL .

CLINICAL SCIENCE, 2003, 104 (04) :349-356

[63] Heparin nebulization attenuates acute lung injury in sepsis following smoke inhalation in sheep [J].

Murakami, K ;

McGuire, R ;

Cox, RQA ;

Jodoin, JM ;

Bjertnaes, LJ ;

Katahira, J ;

Traber, LD ;

Schmalstieg, FC ;

Hawkins, HK ;

Herndon, DN ;

Traber, DL .

SHOCK, 2002, 18 (03) :236-241

[64] A novel animal model of sepsis after acute lung injury in sheep [J].

Murakami, K ;

Bjertnaes, LJ ;

Schmalstieg, FC ;

McGuire, R ;

Cox, RA ;

Hawkins, HK ;

Herndon, DN ;

Traber, LD ;

Traber, DL .

CRITICAL CARE MEDICINE, 2002, 30 (09) :2083-2090

[65] L-arginine attenuates acute lung injury after smoke inhalation and burn injury in sheep [J].

Murakami, Kazunori ;

Enkhbaatar, Perenlei ;

Yu, Yong-Ming ;

Traber, Lillian D. ;

Cox, Robert A. ;

Hawkins, Hal K. ;

Tompkins, Ronald G. ;

Herndon, David ;

Traber, Daniel L. .

SHOCK, 2007, 28 (04) :477-483

[66] ALPHA-TRINOSITOL DECREASES LUNG EDEMA FORMATION AFTER SMOKE-INHALATION IN AN OVINE MODEL [J].

NAKAZAWA, H ;

GUSTAFSSON, TO ;

TRABER, LD ;

HERNDON, DN ;

TRABER, DL .

JOURNAL OF APPLIED PHYSIOLOGY, 1994, 76 (01) :278-282

[67] EFFECTS OF MANGANESE SUPEROXIDE-DISMUTASE ON LUNG FLUID BALANCE AFTER SMOKE-INHALATION [J].

NGUYEN, TT ;

COX, CS ;

HERNDON, DN ;

BIONDO, NA ;

TRABER, LD ;

BUSH, PE ;

ZOPHEL, A ;

TRABER, DL .

JOURNAL OF APPLIED PHYSIOLOGY, 1995, 78 (06) :2161-2168

[68] ADMINISTRATION OF A SYNTHETIC ANTIPROTEASE REDUCES SMOKE-INDUCED LUNG INJURY [J].

NIEHAUS, GD ;

KIMURA, R ;

TRABER, LD ;

HERNDON, DN ;

FLYNN, JT ;

TRABER, DL .

JOURNAL OF APPLIED PHYSIOLOGY, 1990, 69 (02) :694-699

[69] COMPARISON OF EXOGENOUS SURFACTANTS IN THE TREATMENT OF WOOD SMOKE-INHALATION [J].

NIEMAN, GF ;

PASKANIK, AM ;

FLUCK, RR ;

CLARK, WR .

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 1995, 152 (02) :597-602

[70] METHYLPREDNISOLONE DOES NOT PROTECT THE LUNG FROM INHALATION INJURY [J].

NIEMAN, GF ;

CLARK, WR ;

HAKIM, T .

BURNS, 1991, 17 (05) :384-390

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