Animal models of smoke inhalation induced injuries

被引：20

作者：

David, Poon ^{[1
]}

Dunsford, Denny ^{[1
]}

Lu, Jia ^{[1
]}

Moochhala, Shabbir ^{[1
]}

机构：

[1] Def Med & Environm Res Inst, DSO Natl Labs Kent Ridge, Combat Care & Performance Programme, Combat Care Lab, Singapore 117510, Singapore

来源：

FRONTIERS IN BIOSCIENCE-LANDMARK | 2009年 / 14卷

关键词：

Smoke inhalation; Acute lung injury; Animal models; Pathophysiology; Treatment; Therapeutics; Review; ACUTE LUNG INJURY; MANGANESE SUPEROXIDE-DISMUTASE; POSITIVE PRESSURE VENTILATION; COMBINED BURN; VITAMIN-E; NITRIC-OXIDE; PULMONARY-FUNCTION; CARBOXYETHYL-HYDROXYCHROMAN; BRONCHIAL CIRCULATION; CIGARETTE SMOKERS;

D O I：

10.2741/3554

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Smoke inhalation injury is the leading cause of mortality from structural fires, as a result of complications such as systemic inflammatory response syndrome and chronic obstructive pulmonary disease, which can be caused by a localized or systemic response. In this review, the pathophysiology of smoke inhalation injury, along with the characteristics found in clinical settings, common animal models, current treatment methods and future potential therapeutics are discussed.

引用

页码：4618 / 4630

页数：13

共 108 条

[1] LUNG EDEMA FORMATION FOLLOWING INHALATION INJURY - ROLE OF THE BRONCHIAL BLOOD-FLOW [J].