The Contributions of Maternal Sensitivity and Maternal Depressive Symptoms to Epigenetic Processes and Neuroendocrine Functioning

被引：67

作者：

Conradt, Elisabeth ^{[1
]}

Hawes, Katheleen ^{[2
]}

Guerin, Dylan ^{[3
]}

Armstrong, David A. ^{[3
]}

Marsit, Carmen J. ^{[3
]}

Tronick, Edward ^{[4
]}

Lester, Barry M. ^{[2
,5
]}

机构：

[1] Univ Utah, Salt Lake City, UT 84112 USA

[2] Brown Ctr Study Children Risk, Providence, RI USA

[3] Geisel Sch Med Dartmouth, Dartmouth, NS, Canada

[4] Univ Massachusetts, Amherst, MA 01003 USA

[5] Brown Univ, Warren Alpert Med Sch, Providence, RI 02912 USA

来源：

CHILD DEVELOPMENT | 2016年 / 87卷 / 01期

关键词：

DNA METHYLATION; ATTACHMENT SECURITY; STRESS REACTIVITY; STILL-FACE; IN-UTERO; BEHAVIOR; PERSPECTIVE; EXPOSURE; HEALTH; RESILIENCE;

D O I：

10.1111/cdev.12483

中图分类号：

G44 [教育心理学];

学科分类号：

0402 ; 040202 ;

摘要：

This study tested whether maternal responsiveness may buffer the child to the effects of maternal depressive symptoms on DNA methylation of NR3C1, 11-HSD2, and neuroendocrine functioning. DNA was derived from buccal epithelial cells and prestress cortisol was obtained from the saliva of 128 infants. Mothers with depressive symptoms who were more responsive and who engaged in more appropriate touch during face-to-face play had infants with less DNA methylation of NR3C1 and 11-HSD2 compared to mothers with depressive symptoms who were also insensitive. The combination of exposure to maternal depressive symptoms and maternal sensitivity was related to the highest prestress cortisol levels, whereas exposure to maternal depressive symptoms and maternal insensitivity was related to the lowest prestress cortisol levels.

引用

页码：73 / 85

页数：13

共 44 条

[1] Epigenetic regulation of 11β-hydroxysteroid dehydrogenase type 2 expression
Alikhani-Koopaei, R
Fouladkou, F
Frey, FJ
Frey, BM
[J]. JOURNAL OF CLINICAL INVESTIGATION, 2004, 114 (08) : 1146 - 1157
[2] Global and gene-specific DNA methylation across multiple tissues in early infancy: implications for children's health research
Armstrong, David A.
Lesseur, Corina
Conradt, Elisabeth
Lester, Barry M.
Marsit, Carmen J.
[J]. FASEB JOURNAL, 2014, 28 (05) : 2088 - 2097
[3] Barker D. J. P., 1998, MOTHERS BABIES HLTH
[4] BARKER DJP, 1986, LANCET, V1, P1077
[5] Beck A.T., 1987, Manual for the Beck Depression Inventory
[6] Early Resilience in the Context of Parent-Infant Relationships: A Social Developmental Perspective
Beeghly, Marjorie
Tronick, Ed
[J]. CURRENT PROBLEMS IN PEDIATRIC AND ADOLESCENT HEALTH CARE, 2011, 41 (07) : 197 - 201
[7] CONTROLLING THE FALSE DISCOVERY RATE - A PRACTICAL AND POWERFUL APPROACH TO MULTIPLE TESTING
BENJAMINI, Y
HOCHBERG, Y
[J]. JOURNAL OF THE ROYAL STATISTICAL SOCIETY SERIES B-STATISTICAL METHODOLOGY, 1995, 57 (01) : 289 - 300
[8] Chronicity, severity, and timing of maternal depressive symptoms: Relationships with child outcomes at age 5
Brennan, PA
Hammen, C
Andersen, MJ
Bor, W
Najman, JM
Williams, GM
[J]. DEVELOPMENTAL PSYCHOLOGY, 2000, 36 (06) : 759 - 766
[9] Maternal depression and infant cortisol: influences of timing, comorbidity and treatment
Brennan, Patricia A.
Pargas, Rebecca
Walker, Elaine F.
Green, Paula
Newport, D. Jeffrey
Stowe, Zachary
[J]. JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY, 2008, 49 (10) : 1099 - 1107
[10] The course of maternal depressive symptoms and maternal sensitivity as predictors of attachment security at 36 months
Campbell, SB
Brownell, CA
Hungerford, A
Spieker, SJ
Mohan, R
Blessing, JS
[J]. DEVELOPMENT AND PSYCHOPATHOLOGY, 2004, 16 (02) : 231 - 252

← 1 2 3 4 5 →