The Contributions of Maternal Sensitivity and Maternal Depressive Symptoms to Epigenetic Processes and Neuroendocrine Functioning

被引：67
作者：
Conradt, Elisabeth [1 ]
Hawes, Katheleen [2 ]
Guerin, Dylan [3 ]
Armstrong, David A. [3 ]
Marsit, Carmen J. [3 ]
Tronick, Edward [4 ]
Lester, Barry M. [2 ,5 ]
机构：
[1] Univ Utah, Salt Lake City, UT 84112 USA
[2] Brown Ctr Study Children Risk, Providence, RI USA
[3] Geisel Sch Med Dartmouth, Dartmouth, NS, Canada
[4] Univ Massachusetts, Amherst, MA 01003 USA
[5] Brown Univ, Warren Alpert Med Sch, Providence, RI 02912 USA
来源：
CHILD DEVELOPMENT | 2016年 / 87卷 / 01期
关键词：
DNA METHYLATION; ATTACHMENT SECURITY; STRESS REACTIVITY; STILL-FACE; IN-UTERO; BEHAVIOR; PERSPECTIVE; EXPOSURE; HEALTH; RESILIENCE;
D O I：
10.1111/cdev.12483
中图分类号：
G44 [教育心理学];
学科分类号：
0402 ; 040202 ;
摘要：
This study tested whether maternal responsiveness may buffer the child to the effects of maternal depressive symptoms on DNA methylation of NR3C1, 11-HSD2, and neuroendocrine functioning. DNA was derived from buccal epithelial cells and prestress cortisol was obtained from the saliva of 128 infants. Mothers with depressive symptoms who were more responsive and who engaged in more appropriate touch during face-to-face play had infants with less DNA methylation of NR3C1 and 11-HSD2 compared to mothers with depressive symptoms who were also insensitive. The combination of exposure to maternal depressive symptoms and maternal sensitivity was related to the highest prestress cortisol levels, whereas exposure to maternal depressive symptoms and maternal insensitivity was related to the lowest prestress cortisol levels.
引用
收藏
页码：73 / 85
页数：13
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