The CD226 gene in susceptibility of type 1 diabetes

被引：14

作者：

Douroudis, K. ^{[1
]}

Nemvalts, V. ^{[2
]}

Rajasalu, T. ^{[3
]}

Kisand, K. ^{[1
]}

Uibo, R. ^{[1
]}

机构：

[1] Univ Tartu, Immunol Grp, IGMP, EE-51014 Tartu, Estonia

[2] Kuressaare Hosp, Dept Internal Med, Kuressaare, Estonia

[3] Tartu Univ Hosp, Dept Internal Med, Tartu, Estonia

来源：

TISSUE ANTIGENS | 2009年 / 74卷 / 05期

关键词：

CD226; gene; single nucleotide polymorphism (SNP); type; 1; diabetes; ASSOCIATION; DNAM-1;

D O I：

10.1111/j.1399-0039.2009.01320.x

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The rs763361 single nucleotide polymorphism (SNP) within the CD226 gene has recently been reported as a novel susceptible locus for type 1 diabetes. The CD226 gene is implicated in the regulation of a number of cells involved in immune mechanisms leading to beta-cell destruction in type 1 diabetes. The aim of the present study was to confirm the association of the CD226 gene with type 1 diabetes in Estonian population. The TT genotype [odds ratio (OR) = 2.29, 95% confidence interval (CI) = 1.25-4.18, P = 0.0071) and the T allele (OR = 1.48, 95% CI = 1.11-1.98, P = 0.0084) of the rs763361 SNP were associated with the risk of type 1 diabetes. The current study replicates the novel association of the rs763361 SNP in susceptibility of type 1 diabetes and supports the CD226 gene as a susceptible candidate locus for type 1 diabetes outside the major histocompatibility complex region.

引用

页码：417 / 419

页数：3

共 15 条

[1] Transferrin variants as markers of migrations and admixture between populations in the Baltic Sea region [J].

Beckman, L ;

Sikström, C ;

Mikelsaar, AV ;

Krumina, A ;

Ambrasiene, D ;

Kucinskas, V ;

Beckman, G .

HUMAN HEREDITY, 1998, 48 (04) :185-191

[2] SUSCEPTIBILITY TO HUMAN TYPE-1 DIABETES AT IDDM2 IS DETERMINED BY TANDEM REPEAT VARIATION AT THE INSULIN GENE MINISATELLITE LOCUS [J].

BENNETT, ST ;

LUCASSEN, AM ;

GOUGH, SCL ;

POWELL, EE ;

UNDLIEN, DE ;

PRITCHARD, LE ;

MERRIMAN, ME ;

KAWAGUCHI, Y ;

DRONSFIELD, MJ ;

POCIOT, F ;

NERUP, J ;

BOUZEKRI, N ;

CAMBONTHOMSEN, A ;

RONNINGEN, KS ;

BARNETT, AH ;

BAIN, SC ;

TODD, JA .

NATURE GENETICS, 1995, 9 (03) :284-292

[3] The expanding genetic overlap between multiple sclerosis and type I diabetes [J].

Booth, David R. ;

Heard, Robert N. ;

Stewart, Graeme J. ;

Goris, An ;

Dobosi, Rita ;

Dubois, Benedicte ;

Lorentzen, Aslaug R. ;

Celius, Elisabeth G. ;

Harbo, Hanne F. ;

Spurkland, Anne ;

Olsson, Tomas ;

Kockum, Ingrid ;

Link, Jenny ;

Hillert, Jan ;

Ban, Maria ;

Baker, Amie ;

Sawcer, Stephen ;

Compston, Alastair ;

Mihalova, Tania ;

Strange, Richard ;

Hawkins, Clive ;

Ingram, Gillian ;

Robertson, Neil P. ;

De Jager, Philip L. ;

Hafler, David A. ;

Barcellos, Lisa F. ;

Ivinson, Adrian J. ;

Pericak-Vance, Margaret ;

Oksenberg, Jorge R. ;

Hauser, Stephen L. ;

McCauley, Jacob L. ;

Sexton, David ;

Haines, Jonathan .

GENES AND IMMUNITY, 2009, 10 (01) :11-14

[4] A functional variant of lymphoid tyrosine phosphatase is associated with type I diabetes [J].

Bottini, N ;

Musumeci, L ;

Alonso, A ;

Rahmouni, S ;

Nika, K ;

Rostamkhani, M ;

MacMurray, J ;

Meloni, GF ;

Lucarelli, P ;

Pellecchia, M ;

Eisenbarth, GS ;

Comings, D ;

Mustelin, T .

NATURE GENETICS, 2004, 36 (04) :337-338

[5] Identification of PVR (CD155) and nectin-2 (CD112) as cell surface ligands for the human DNAM-1 (CD226) activating molecule [J].

Bottino, C ;

Castriconi, R ;

Pende, D ;

Rivera, P ;

Nanni, M ;

Carnemolla, B ;

Cantoni, C ;

Grassi, J ;

Marcenaro, S ;

Reymond, N ;

Vitale, M ;

Moretta, L ;

Lopez, M ;

Moretta, A .

JOURNAL OF EXPERIMENTAL MEDICINE, 2003, 198 (04) :557-567

[6] RETRACTED: CD226 expression deficiency causes high sensitivity to apoptosis in NKT cells from patients with systemic lupus erythematosus (Retracted Article) [J].

Deng, T ;

Liu, SW ;

Wu, Q ;

Liu, Y ;

Ju, W ;

Liu, JY ;

Gong, FL ;

Jin, BQ ;

Tan, JQ .

JOURNAL OF IMMUNOLOGY, 2005, 174 (03) :1281-1290

[7]

Gavin JR, 1999, DIABETES CARE, V22, pS5

[8] CD226 Gly307Ser association with multiple autoimmune diseases [J].

Hafler, J. P. ;

Maier, L. M. ;

Cooper, J. D. ;

Plagnol, V. ;

Hinks, A. ;

Simmonds, M. J. ;

Stevens, H. E. ;

Walker, N. M. ;

Healy, B. ;

Howson, J. M. M. ;

Maisuria, M. ;

Duley, S. ;

Coleman, G. ;

Gough, S. C. L. ;

Worthington, J. ;

Kuchroo, V. K. ;

Wicker, L. S. ;

Todd, J. A. .

GENES AND IMMUNITY, 2009, 10 (01) :5-10

[9] ALLELIC SEQUENCE VARIATION OF THE HLA-DQ LOCI - RELATIONSHIP TO SEROLOGY AND TO INSULIN-DEPENDENT DIABETES SUSCEPTIBILITY [J].

HORN, GT ;

BUGAWAN, TL ;

LONG, CM ;

ERLICH, HA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1988, 85 (16) :6012-6016

[10] SHEsis, a powerful software platform for analyses of linkage disequilibrium, haplotype construction, and genetic association at polymorphism loci [J].

Shi, YY ;

He, L .

CELL RESEARCH, 2005, 15 (02) :97-98

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