Repetitive nerve stimulation cutoff values for the diagnosis of myasthenia gravis

被引：33

作者：

Abraham, Alon ^{[1
]}

Alabdali, Majed ^{[2
]}

Alsulaiman, Abdulla ^{[2
]}

Breiner, Ari ^{[1
]}

Barnett, Carolina ^{[1
]}

Katzberg, Hans D. ^{[1
]}

Lovblom, Leif E. ^{[3
,4
]}

Bril, Vera ^{[1
]}

机构：

[1] Toronto Gen Hosp, Univ Hlth Network, Ellen & Martin Prosserman Ctr Neuromuscular Dis, Div Neurol,Dept Med, 200 Elizabeth St,Room 5 EB 309, Toronto, ON M5G 2C4, Canada

[2] Univ Dammam, Dept Neurol, King Fahad Hosp Univ, Dammam, Saudi Arabia

[3] Univ Toronto, Div Endocrinol & Metab, Mt Sinai Hosp, Toronto, ON, Canada

[4] Univ Toronto, Lunenfeld Tanenbaum Res Inst, Toronto, ON, Canada

来源：

MUSCLE & NERVE | 2017年 / 55卷 / 02期

关键词：

myasthenia gravis; repetitive nerve stimulation; sensitivity; single fiber EMG; specificity; SENSITIVITY;

D O I：

10.1002/mus.25214

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

IntroductionRepetitive nerve stimulation (RNS) showing10% decrement is considered the cutoff for myasthenia gravis (MG), but this has never been validated. The objective of this study was to find an optimal validated cutoff value for decrement on RNS. Methods: We performed retrospective chart review of patients who had electrophysiological assessment for possible MG from 2013 to 2015. Results: A total of 122 patients with MG and 182 controls were identified. RNS sensitivities for generalized and ocular MG using the traditional 10% cutoff value were 46% and 15%, respectively, for frontalis recordings, and 35% and 19%, respectively, for nasalis recordings. Using a decrement cutoff value of 7% for frontalis and 8% for nasalis increased the sensitivities by 6-11%, with specificities of 95-96%. Conclusions: For RNS in facial muscles, we suggest a cutoff value of 7-8%, which increases test sensitivity by 6-11%, while preserving high specificity for the diagnosis of MG. Muscle Nerve, 2016 Muscle Nerve55: 166-170, 2017

引用

页码：166 / 170

页数：5

共 12 条

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AAEM Quality Assurance Comm, 2001, MUSCLE NERVE, V24, P1239

[2]

Amato A. A., 2008, NEUROMUSCULAR DISORD

[3] SINGLE-FIBER EMG REFERENCE VALUES - REFORMATTED IN TABULAR FORM [J].