Bioactive eudesmane and germacrane derivatives from Inula wissmanniana Hand.-Mazz.

被引：22

作者：

Cheng, Xiang-Rong ^{[1
,2
]}

Zhang, Shou-De ^{[3
]}

Wang, Chun-Hui ^{[1
]}

Ren, Jie ^{[1
]}

Qin, Jiang-Jiang ^{[1
]}

Tang, Xue ^{[2
]}

Shen, Yun-Heng ^{[4
]}

Yan, Shi-Kai ^{[1
]}

Jin, Hui-Zi ^{[1
]}

Zhang, Wei-Dong ^{[1
,4
]}

机构：

[1] Shanghai Jiao Tong Univ, Sch Pharm, Shanghai 200240, Peoples R China

[2] Jiangnan Univ, Sch Food Sci & Technol, Wuxi 214122, Jiangsu, Peoples R China

[3] E China Univ Sci & Technol, Sch Pharm, Shanghai 200237, Peoples R China

[4] Second Mil Med Univ, Sch Pharm, Shanghai 200433, Peoples R China

来源：

PHYTOCHEMISTRY | 2013年 / 96卷

关键词：

Inula wissmanniana Hand.-Mazz; Asteraceae; Eudesmane; Germacrane; NO production; Cytotoxicity;

D O I：

10.1016/j.phytochem.2013.10.006

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Phytochemical investigation of Inula wissmanniana Hand.-Mazz. afforded 21 eudesmane and germacrane derivatives, including rare 4,5-secoeudesman-12,5-olide, eudesman-12,5-olide, 3,4-secoeudesman-12-oic acid, and germacra-4-en-12,6-olides. Their structures were elucidated by combinative analyses of MS, NMR, electronic circular dichroism, and X-ray crystallography data. Moreover, most of the isolates exhibited inhibition against lipopolysaccharide-induced nitric oxide production in RAW264.7 macrophages and cytotoxicity in HepG2, PC-3, and MGC-803 tumor cells. (C) 2013 Elsevier Ltd. All rights reserved.

引用

页码：214 / 222

页数：9

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