Simultaneous Dual Encoding of Three-Dimensional Structures by Light-Induced Modular Ligation

被引：50

作者：

Claus, Tanja K. ^{[1
,2
]}

Richter, Benjamin ^{[3
]}

Hahn, Vincent ^{[5
,6
]}

Welle, Alexander ^{[1
,2
]}

Kayser, Sven ^{[4
]}

Wegener, Martin ^{[5
,6
]}

Bastmeyer, Martin ^{[3
,7
]}

Delaittre, Guillaume ^{[1
,8
]}

Barner-Kowollik, Christopher ^{[1
,2
]}

机构：

[1] Karlsruhe Inst Technol, Inst Tech Chem & Polymerchem, Preparat Macromol Chem, Engesserstr 18, D-76131 Karlsruhe, Germany

[2] Karlsruhe Inst Technol, Inst Biol Grenzflachen, Hermann von Helmholtz Pl 1, D-76344 Eggenstein Leopoldshafen, Germany

[3] Karlsruhe Inst Technol, Cell & Neurobiol Zool Inst, Haid & Neu Str 9, D-76131 Karlsruhe, Germany

[4] ION TOF GmbH, Heisenbergstr 15, D-48149 Munster, Germany

[5] Karlsruhe Inst Technol, Inst Appl Phys, Wolfgang Gaede Str 1, D-76131 Karlsruhe, Germany

[6] Karlsruhe Inst Technol, Inst Nanotechnol, Wolfgang Gaede Str 1, D-76131 Karlsruhe, Germany

[7] Karlsruhe Inst Technol, Inst Funkt Grenzflachen, Hermann von Helmholtz Pl 1, D-76344 Eggenstein Leopoldshafen, Germany

[8] Karlsruhe Inst Technol, Inst Toxicol & Genet, Hermann von Helmholtz Pl 1, D-76344 Eggenstein Leopoldshafen, Germany

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2016年 / 55卷 / 11期

关键词：

cycloaddition; direct laser writing; microstructures; patterning; photochemistry; CONTROLLED SURFACE IMMOBILIZATION; FUNCTIONALIZATION; MICROSTRUCTURES; FABRICATION; SCAFFOLDS; DESIGN; ALKYNE;

D O I：

10.1002/anie.201509937

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A highly efficient strategy for the simultaneous dual surface encoding of 2D and 3D microscaffolds is reported. The combination of an oligo(ethylene glycol)-based network with two novel and readily synthesized monomers with photoreactive side chains yields two new photoresists, which can be used for the fabrication of microstructures (by two-photon polymerization) that exhibit a dual-photoreactive surface. By combining both functional photoresists into one scaffold, a dual functionalization pattern can be obtained by a single irradiation step in the presence of adequate reaction partners based on a self-sorting mechanism. The versatility of the approach is shown by the dual patterning of halogenated and fluorescent markers as well as proteins. Furthermore, we introduce a new ToF-SIMS mode (delayed extraction) for the characterization of the obtained microstructures that combines high mass resolution with improved lateral resolution.

引用

页码：3817 / 3822

页数：6

共 45 条

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Altintas O., 2015, ANGEW CHEM, V127, P5869

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