Implication of abnormal epigenetic patterns for human diseases

被引:78
作者
Santos-Reboucas, C. B. [1 ]
Pimentel, M. M. G. [1 ]
机构
[1] Univ Estado Rio De Janeiro, Dept Biol Celular & Genet, Serv Genet Humana, Inst Biol Roberto Alcantara Gomes, BR-20550013 Rio De Janeiro, Brazil
关键词
epigenetic diseases; epigenome; DNA methylation; imprinting; chromatin remodeling; PcG proteins;
D O I
10.1038/sj.ejhg.5201727
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Significant evidences have brought new insights on the mechanisms by which epigenetic machinery proteins regulate gene expression, leading to a redefinition of chromatin regulation in terms of modification of core histones, DNA methylation, RNA-mediated silencing pathways, action of methylation-dependent sensitive insulators and Polycomb/Trithorax group proteins. Consistent with these fundamental aspects, an increasing number of human pathologies have been found to be associated with aberrant epigenetics regulation, including cancer, mental retardation, neurodegenerative symptoms, imprinting disorders, syndromes involving chromosomal instabilities and a great number of human life-threatening diseases. The possibility of reversing epigenetic marks, in contrast to genetic code, may provide new pharmacological targets for emerging therapeutic intervention.
引用
收藏
页码:10 / 17
页数:8
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