Dendritic cell function in lupus: Independent contributors or victims of aberrant immune regulation

被引：27

作者：

Kis-Toth, Katalin ^{[1
]}

Tsokos, George C. ^{[1
]}

机构：

[1] Harvard Univ, Sch Med, Harvard Inst Med, Beth Israel Deaconess Med Ctr,Div Rheumatol, Boston, MA 02115 USA

来源：

AUTOIMMUNITY | 2010年 / 43卷 / 02期

关键词：

TOLL-LIKE RECEPTORS; CD34(+) HEMATOPOIETIC PROGENITORS; CORD BLOOD DIFFERENTIATE; ANTIGEN-PRESENTING CELLS; NECROSIS-FACTOR-ALPHA; APOPTOTIC CELLS; T-CELL; IFN-ALPHA; B-CELLS; HUMAN-MONOCYTES;

D O I：

10.3109/08916930903214041

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Dendritic cells (DCs) represent an important component of the immune system connecting the innate and adaptive immune responses. They are able to trigger strong immunity as well as tolerance against certain antigens, and therefore it is obvious that they have a central role in the expression of immunological diseases. However, because DCs are sparse, heterogeneous and plastic, their exact role in complex autoimmune diseases, such as systemic lupus erythematosus (SLE) remains not well defined. In this review, we make an attempt to summarize critically recent knowledge on the role of conventional DCs in the expression of autoimmunity and pathology in SLE.</.

引用

页码：121 / 130

页数：10

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