Prevalence of hepatitis C virus infection in patients with COPD

被引:21
作者
Silva, D. R. [1 ]
Stifft, J. [2 ]
Cheinquer, H. [2 ]
Knorst, M. M. [1 ]
机构
[1] Univ Fed Rio Grande do Sul, Hosp Clin Porto Alegre, Div Pulm, BR-90046900 Porto Alegre, RS, Brazil
[2] Univ Fed Rio Grande do Sul, Hosp Clin Porto Alegre, Div Gastroenterol, BR-90046900 Porto Alegre, RS, Brazil
关键词
COPD; HCV infection; prevalence; OBSTRUCTIVE PULMONARY-DISEASE; BRONCHOALVEOLAR LAVAGE FLUID; AIR-FLOW OBSTRUCTION; RISK-FACTORS; LUNG-VOLUMES; STANDARDIZATION; INFLAMMATION; LYMPHOCYTES; MANAGEMENT; EMPHYSEMA;
D O I
10.1017/S0950268809990276
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
Some studies have suggested that chronic hepatitis C virus (HCV) infection may induce an accelerated decline of forced expiratory Volume in I second (FEV(1)). We performed a cross-sectional study to determine the Prevalence of HCV infection in a sample of chronic obstructive pulmonary disease (COPD) patients and in a control group of blood donors. The clinical characteristics of HCV-positive and HCV-negative patients were compared. Anti-HCV antibody was determined and confirmed by HCV-RNA. The prevalence of HCV infection in COPD patients was 7.5% (95% Cl 6.52-8.48) and in blood donors was 0.41% (95% Cl 0.40-0.42). The HCV-positive patients had a lower FEV(1) (34.7 +/- 8.6%) and a higher BODE index (median=6) than HCV-negative patients (42.7 +/- 16.5%, median=4, respectively) (P = 0.011 and 0.027, respectively). Our results suggest a high prevalence of chronic HCV infection in patients with COPD in comparison with the blood donors. HCV-positive patients have a more severe disease.
引用
收藏
页码:167 / 173
页数:7
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