Development of liquid chromatography atmospheric pressure chemical ionization tandem mass spectrometry for analysis of halogenated flame retardants in wastewater

被引：46

作者：

Zhou, Simon Ningsun ^{[1
,2
]}

Reiner, Eric J. ^{[2
]}

Marvin, Chris ^{[3
]}

Helm, Paul ^{[4
]}

Riddell, Nicole ^{[5
]}

Dorman, Frank ^{[6
,7
]}

Misselwitz, Michelle ^{[6
]}

Shen, Li ^{[1
,2
]}

Crozier, Patrick ^{[2
]}

MacPherson, Karen ^{[2
]}

Brindle, Ian D. ^{[1
]}

机构：

[1] Brock Univ, Dept Chem, St Catharines, ON L2S 3A1, Canada

[2] Ontario Minist Environm, Lab Serv Branch, Toronto, ON M9P 3V6, Canada

[3] Environm Canada, Natl Water Res Inst, Burlington, ON L7R 4A6, Canada

[4] Ontario Minist Environm, Environm Monitoring & Reporting Branch, Toronto, ON M9P 3V6, Canada

[5] Wellington Labs, Guelph, ON N1G 3M5, Canada

[6] Restek Corp, Bellefonte, PA 16823 USA

[7] Juniata Coll, Dept Chem, Huntingdon, PA 16652 USA

来源：

ANALYTICAL AND BIOANALYTICAL CHEMISTRY | 2010年 / 396卷 / 03期

关键词：

Atmospheric pressure chemical ionization (APCI); Liquid chromatography tandem mass spectrometry (LC-MS/MS); Halogenated flame retardants (HFRs); Wastewater; DIPHENYL ETHERS PBDES; TETRABROMOBISPHENOL-A; ENVIRONMENTAL-SAMPLES; HOUSE-DUST; HEXABROMOCYCLODODECANE; PHOTOIONIZATION; SEDIMENT; SLUDGE;

D O I：

10.1007/s00216-009-3279-6

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Until recently, atmospheric pressure photoionization (APPI) has typically been used for the determination of non-polar halogenated flame retardants (HFRs) by liquid chromatography (LC) tandemmass spectrometry. In this study, we demonstrated the feasibility of utilizing liquid chromatography atmospheric pressure chemical ionization (APCI) tandem mass spectrometry (LC-APCI-MS/MS) for analysis of 38 HFRs. This developed method offered three advantages: simplicity, rapidity, and high sensitivity. Compared with APPI, APCI does not require a UV lamp and a dopant reagent to assist atmospheric pressure ionization. All the isomers and the isobaric compounds were well resolved within 14-min LC separation time. Excellent instrument detection limits (6.1 pg on average with 2.0 mu L injection) were observed. The APCI mechanism was also investigated. The method developed has been applied to the screening of wastewater samples for screening purpose, with concentrations determined by LCAPCI-MS/MS agreeing with data obtained via gas chromatography high resolution mass spectrometry.

引用

页码：1311 / 1320

页数：10

共 28 条

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