COVID-19 and the human innate immune system

被引：499

作者：

Schultze, Joachim L. ^{[1
,2
,3
,4
]}

Aschenbrenner, Anna C. ^{[1
,2
,3
,4
,5
,6
]}

机构：

[1] German Ctr Neurodegenerat Dis DZNE, Syst Med, Bonn, Germany

[2] DZNE, PRECISE Platform Single Cell Genom & Epigen, Bonn, Germany

[3] Univ Bonn, Bonn, Germany

[4] Univ Bonn, Life & Med Sci Limes Inst, Genom & Immunoregulat, Bonn, Germany

[5] Radboud Univ Nijmegen, Dept Internal Med, Med Ctr, Nijmegen, Netherlands

[6] Radboud Univ Nijmegen, Radboud Ctr Infect Dis RCI, Med Ctr, Nijmegen, Netherlands

来源：

CELL | 2021年 / 184卷 / 07期

关键词：

BCG VACCINATION; I INTERFERON; SARS-COV-2; INFECTION; RESPONSES; RECEPTOR; PROTECTS; REVEALS; CELLS; SPIKE;

D O I：

10.1016/j.cell.2021.02.029

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The introduction of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) into the human population represents a tremendous medical and economic crisis. Innate immunity-as the first line of defense of our immune system-plays a central role in combating this novel virus. Here, we provide a conceptual framework for the interaction of the human innate immune system with SARS-CoV-2 to link the clinical observations with experimental findings that have been made during the first year of the pandemic. We review evidence that variability in innate immune system components among humans is a main contributor to the heterogeneous disease courses observed for coronavirus disease 2019 (COVID-19), the disease spectrum induced by SARS-CoV-2. A better understanding of the pathophysiological mechanisms observed for cells and soluble mediators involved in innate immunity is a prerequisite for the development of diagnostic markers and therapeutic strategies targeting COVID-19. However, this will also require additional studies addressing causality of events, which so far are lagging behind.

引用

页码：1671 / 1692

页数：22

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