Telomeres, p21 and the cancer-aging hypothesis

被引：16
作者：
Bell, Jessica F. [1 ]
Sharpless, Norman E.
机构：
[1] Univ N Carolina, Dept Med, Lineberger Comprehens Canc Ctr, Sch Med, Chapel Hill, NC 27599 USA
[2] Univ N Carolina, Dept Genet, Lineberger Comprehens Canc Ctr, Sch Med, Chapel Hill, NC 27599 USA
来源：
NATURE GENETICS | 2007年 / 39卷 / 01期
关键词：
D O I：
10.1038/ng0107-11
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Telomere dysfunction suppresses cancer through the p53 tumor suppressor pathway but also contributes to aging. A new study suggests that these effects of dysfunctional telomeres may be separable, such that aging - but not cancer suppression - depends on the p21 cell cycle inhibitor.
引用
收藏
页码：11 / 12
页数：2
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