共 27 条
Interaction between Tie receptors modulates angiogenic activity of angiopoietin2 in endothelial progenitor cells
被引:60
作者:

Kim, Koung Li
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机构: Pochon CHA Univ, Grad Sch Life Sci & Biotechnol, CHA Stem Cell Inst, Seoul 135907, South Korea

Shin, In-Soon
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机构: Pochon CHA Univ, Grad Sch Life Sci & Biotechnol, CHA Stem Cell Inst, Seoul 135907, South Korea

Kim, Jeong-Min
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机构: Pochon CHA Univ, Grad Sch Life Sci & Biotechnol, CHA Stem Cell Inst, Seoul 135907, South Korea

Choi, Jin-Ho
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机构: Pochon CHA Univ, Grad Sch Life Sci & Biotechnol, CHA Stem Cell Inst, Seoul 135907, South Korea

Byun, Jonghoe
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机构: Pochon CHA Univ, Grad Sch Life Sci & Biotechnol, CHA Stem Cell Inst, Seoul 135907, South Korea

Jeon, Eun-Seok
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机构: Pochon CHA Univ, Grad Sch Life Sci & Biotechnol, CHA Stem Cell Inst, Seoul 135907, South Korea

Suh, Wonhee
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机构: Pochon CHA Univ, Grad Sch Life Sci & Biotechnol, CHA Stem Cell Inst, Seoul 135907, South Korea

Kim, Duk-Kyung
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机构: Pochon CHA Univ, Grad Sch Life Sci & Biotechnol, CHA Stem Cell Inst, Seoul 135907, South Korea
机构:
[1] Pochon CHA Univ, Grad Sch Life Sci & Biotechnol, CHA Stem Cell Inst, Seoul 135907, South Korea
[2] Sungkyunkwan Univ, Sch Med, Samsung Biomed Res Inst, Samsung Med Ctr,Dept Med, Seoul 135710, South Korea
[3] Dankook Univ, Inst Nanosensor & Biotechnol, Dept Biol Mol, Seoul 140714, South Korea
关键词:
angiogenesis;
angiopoietin2;
endothelial progenitor cell;
Tie1;
Tie2;
D O I:
10.1016/j.cardiores.2006.08.002
中图分类号:
R5 [内科学];
学科分类号:
1002 ;
100201 ;
摘要:
Objective: Ischemia-dependent upregulation of angiopoietin2 (Ang2) led us to hypothesize the potentially proangiogenic Ang2-Tie2 signaling in endothelial progenitor cells (EPCs). Given the well-known vascular destabilizing action of Ang2 in mature endothelium, we investigated the yet unidentified mechanism behind cell-dependent differential activity of Ang2. Methods and results: Both in vitro and in vivo experiments showed that Ang2 promoted angiogenicity of human cord blood-derived EPCs, where Ang2 directly activated Tie2 and its related downstream signaling molecules. However, Ang2 had no such effect in fully differentiated human umbilical vein endothelial cells (HUVECs) under the same condition. Such a cell-dependent Tie2 activation by Ang2 was explained by comparing EPCs and HUVECs, where most Tie2 receptors in EPCs were found to be present unbound to Tie I, whereas those in HUVECs existed as heterocomplexes with Tiel. When Tie2 in HUVECs was prevented from forming heterocomplexes by silencing Tiel expression, they underwent rapid phosphorylation upon Ang2 treatment, as shown in EPCs. Conclusions: In contrast with its roles in mature endothelial cells, Ang2 has proangiogenic activities in EPC directly through Tie2 signaling pathway. Such a cell-dependent differential reactivity of Ang2 was for the first time found to be modulated by physical association between Tiel and Tie2, which inhibited Ang2-mediated Tie2 activation. (c) 2006 European Society of Cardiology. Published by Elsevier B.V. All rights reserved.
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页码:394 / 402
页数:9
相关论文
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h-index: 0
机构: Univ Helsinki, Biomedicum Inst, Ludwig Inst Canc Res, Mol Canc Biol Lab, SF-00014 Helsinki, Finland

Iljin, K
论文数: 0 引用数: 0
h-index: 0
机构: Univ Helsinki, Biomedicum Inst, Ludwig Inst Canc Res, Mol Canc Biol Lab, SF-00014 Helsinki, Finland

Dumont, DJ
论文数: 0 引用数: 0
h-index: 0
机构: Univ Helsinki, Biomedicum Inst, Ludwig Inst Canc Res, Mol Canc Biol Lab, SF-00014 Helsinki, Finland

Alitalo, K
论文数: 0 引用数: 0
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机构: Univ Helsinki, Biomedicum Inst, Ludwig Inst Canc Res, Mol Canc Biol Lab, SF-00014 Helsinki, Finland
[10]
Transplantation of ex vivo expanded endothelial progenitor cells for therapeutic neovascularization
[J].
Kalka, C
;
Masuda, H
;
Takahashi, T
;
Kalka-Moll, WM
;
Silver, M
;
Kearney, M
;
Li, T
;
Isner, JM
;
Asahara, T
.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,
2000, 97 (07)
:3422-3427

Kalka, C
论文数: 0 引用数: 0
h-index: 0
机构: Tufts Univ, Sch Med, St Elizabeths Med Ctr, Dept Med Cardiovasc Res, Boston, MA 02135 USA

Masuda, H
论文数: 0 引用数: 0
h-index: 0
机构: Tufts Univ, Sch Med, St Elizabeths Med Ctr, Dept Med Cardiovasc Res, Boston, MA 02135 USA

Takahashi, T
论文数: 0 引用数: 0
h-index: 0
机构: Tufts Univ, Sch Med, St Elizabeths Med Ctr, Dept Med Cardiovasc Res, Boston, MA 02135 USA

Kalka-Moll, WM
论文数: 0 引用数: 0
h-index: 0
机构: Tufts Univ, Sch Med, St Elizabeths Med Ctr, Dept Med Cardiovasc Res, Boston, MA 02135 USA

Silver, M
论文数: 0 引用数: 0
h-index: 0
机构: Tufts Univ, Sch Med, St Elizabeths Med Ctr, Dept Med Cardiovasc Res, Boston, MA 02135 USA

Kearney, M
论文数: 0 引用数: 0
h-index: 0
机构: Tufts Univ, Sch Med, St Elizabeths Med Ctr, Dept Med Cardiovasc Res, Boston, MA 02135 USA

Li, T
论文数: 0 引用数: 0
h-index: 0
机构: Tufts Univ, Sch Med, St Elizabeths Med Ctr, Dept Med Cardiovasc Res, Boston, MA 02135 USA

Isner, JM
论文数: 0 引用数: 0
h-index: 0
机构: Tufts Univ, Sch Med, St Elizabeths Med Ctr, Dept Med Cardiovasc Res, Boston, MA 02135 USA

Asahara, T
论文数: 0 引用数: 0
h-index: 0
机构: Tufts Univ, Sch Med, St Elizabeths Med Ctr, Dept Med Cardiovasc Res, Boston, MA 02135 USA