Histopathology of aging of the hair follicle

被引：36

作者：

Fernandez-Flores, Angel ^{[1
,2
,3
]}

Saeb-Lima, Marcela ^{[4
,5
]}

Cassarino, David S. ^{[6
]}

机构：

[1] Hosp El Bierzo, Dept Cellular Pathol, Ponferrada, Spain

[2] Biomed Invest Inst A Coruna, SB Res Grp, Dept CellCOM, La Coruna, Spain

[3] Hosp Reina, Dept Cellular Pathol, Ponferrada, Spain

[4] Inst Nacl Ciencias Med & Nutr Salvador Zubiran, Dept Dermatol, Mexico City, DF, Mexico

[5] Inst Nacl Ciencias Med & Nutr Salvador Zubiran, Dept Dermatopathol, Mexico City, DF, Mexico

[6] Southern Calif Kaiser Permanente, LAMC, Dept Pathol, Los Angeles, CA USA

来源：

JOURNAL OF CUTANEOUS PATHOLOGY | 2019年 / 46卷 / 07期

关键词：

aging; graying; hair follicle; hair pigmentation; white hair; MELANOCYTE STEM-CELLS; OUTER ROOT SHEATH; ANTI-PD-L1; IMMUNOTHERAPY; SCALP HAIR; SENESCENT ALOPECIA; GROWTH; REPIGMENTATION; SKIN; PIGMENTATION; MELANOGENESIS;

D O I：

10.1111/cup.13467

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Hair follicles experience several changes with aging, the most noticeable of which is graying of the hair shaft due to loss of melanin. Additional changes in the diameter and length of the hair have contributed to the concept of senescent alopecia, which is different from androgenetic alopecia according to most. Graying happens in most individuals, although in different grades and starting at different ages. It is related to a decrease in the number and activity of the melanocytes of the hair bulb, which eventually completely disappear from the bulb of the white hair. Residual non-active melanocytes remain in the outer root sheath and in the bulge, which allows for repigmentation of the hair under certain stimuli or conditions.

引用

页码：508 / 519

页数：12

共 89 条

[1] Antioxidant enzymes and lipid peroxidation in the scalp of patients with alopecia areata [J].

Akar, A ;

Arca, E ;

Erbil, HA ;

Akay, C ;

Sayal, A ;

Gür, AR .

JOURNAL OF DERMATOLOGICAL SCIENCE, 2002, 29 (02) :85-90

[2]

[Anonymous], 1988, KOSHOKAISHI

[3] Towards a "free radical theory of graying": melanocyte apoptosis in the aging human hair follicle is an indicator of oxidative stress induced tissue damage [J].

Arck, Petra Clara ;

Overall, Rupert ;

Spatz, Katharina ;

Liezman, Christiane ;

Handjiski, Bori ;

Klapp, Burghard F. ;

Birch-Machin, Mark A. ;

Peters, Eva Milena Johanne .

FASEB JOURNAL, 2006, 20 (09) :1567-+

[4] RE-PIGMENTATION OF HAIR FOLLOWING PHOTOSENSITIVE DERMATITIS [J].

BHUTANI, LK ;

MINOCHA, YK ;

DHIR, GG ;

RAO, DS .

DERMATOLOGICA, 1978, 156 (02) :101-104

[5] Hair density, hair diameter and the prevalence of female pattern hair loss [J].

Birch, MP ;

Messenger, JF ;

Messenger, AG .

BRITISH JOURNAL OF DERMATOLOGY, 2001, 144 (02) :297-304

[6] Erlotinib-induced hair repigmentation [J].

Cheng, Yu-Pin ;

Chen, Hsiang-Jung ;

Chiu, Hsien-Ching .

INTERNATIONAL JOURNAL OF DERMATOLOGY, 2014, 53 (01) :E55-E57

[7] Hair greying is associated with active hair growth [J].

Choi, H. I. ;

Choi, G. I. ;

Kim, E. K. ;

Choi, Y. J. ;

Sohn, K. C. ;

Lee, Y. ;

Kim, C. D. ;

Yoon, T. J. ;

Sohn, H. J. ;

Han, S. H. ;

Kim, S. ;

Lee, J. H. ;

Lee, Y. H. .

BRITISH JOURNAL OF DERMATOLOGY, 2011, 165 (06) :1183-1189

[8] Changing expression of the genes related to human hair graying [J].

Choi, Young Jin ;

Yoon, Tae Jin ;

Lee, Young Ho .

EUROPEAN JOURNAL OF DERMATOLOGY, 2008, 18 (04) :397-399

[9] Human hair greying is linked to a specific depletion of hair follicle melanocytes affecting both the bulb and the outer root sheath [J].

Commo, S ;

Gaillard, O ;

Bernard, BA .

BRITISH JOURNAL OF DERMATOLOGY, 2004, 150 (03) :435-443

[10] Melanocyte subpopulation turnover during the human hair cycle: An immunohistochemical study [J].

Commo, S ;

Bernard, BA .

PIGMENT CELL RESEARCH, 2000, 13 (04) :253-259

← 1 2 3 4 5 6 7 8 9 →