L-Glutamine Supplementation Alleviates Constipation during Late Gestation of Mini Sows by Modifying the Microbiota Composition in Feces

被引：45

作者：

Zhang, Yuanyuan ^{[1
]}

Lu, Taofeng ^{[1
]}

Han, Lingxia ^{[1
]}

Zhao, Lili ^{[1
]}

Niu, Yinjie ^{[1
]}

Chen, Hongyan ^{[1
]}

机构：

[1] Chinese Acad Agr Sci, Harbin Vet Res Inst, Lab Anim & Comparat Med, State Key Lab Vet Biotechnol, Harbin 150069, Peoples R China

来源：

BIOMED RESEARCH INTERNATIONAL | 2017年 / 2017卷

基金：

中国国家自然科学基金;

关键词：

GUT MICROBIOTA; INTESTINAL MICROBIOTA; AMINO-ACIDS; METABOLISM; DIET; SEQUENCES; FLORA; PIG;

D O I：

10.1155/2017/4862861

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Constipation occurs frequently in both sows and humans, particularly, during late gestation. The microbial community of the porcine gut, the enteric microbiota, plays a critical role in functions that sustain intestinal health. Hence, microbial regulation during pregnancy may be important to prevent host constipation. The present study was conducted to determine whether L-glutamine (Gln) supplementation improved intestinal function and alleviated constipation by regulation of enteric microbiota. 16S rRNA sequences obtained from fecal samples from 9 constipated sows (3 in the constipation group and 6 in the 1.0% Gln group) were assessed from gestational day 70 to 84. Comparative analysis showed that the abundance of intestinal-friendly microbiota, that is, Bacteroidetes (P = 0.007) and Actinobacteria (P = 0.037), was comparatively increased in the 1.0% Gln group, while the abundance of pernicious bacteria, Oscillospira (P < 0.001) and Treponema (P = 0.011), was decreased. Dietary supplementation with 1.0% Gln may ameliorate constipation of sows by regulated endogenous gut microbiota.

引用

页数：9

共 56 条

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