Recent Advances in Direct C-H Bond Functionalization of Phenylalanine Derivatives

被引：5

作者：

Li, Xiaofang ^{[1
]}

Xiong, Weikang ^{[1
]}

Ding, Qiuping ^{[1
]}

机构：

[1] Jiangxi Normal Univ, Coll Chem & Chem Engn, Key Lab Small Funct Organ Mol, Minist Educ, Nanchang 330022, Jiangxi, Peoples R China

来源：

CHINESE JOURNAL OF ORGANIC CHEMISTRY | 2019年 / 39卷 / 07期

基金：

中国国家自然科学基金;

关键词：

phenylalanine; C-H functionalization; alkylation; alkenylation; arylation; REGIOSPECIFIC SYNTHESIS; NITRATION; PICOLINAMIDE; NITROARENES; ACTIVATION; AMINATION; ARYLATION; DELTA; SP(2);

D O I：

10.6023/cjoc201901029

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Phenylalanine derivatives are widely found in a broad range of pharmaceutical molecules and exhibit significant biological activity. Direct C-H bond functionalization of phenylalanine derivatives to offer an efficient approach to construct C-I, C(sp(2))-C(sp(2)), C(sp(2))-C(sp), C(sp(2))-C(sp(3)), C-N, C-B and C-O bonds is described. The transformation involves ortho-C-H bond iodination and the following intramolecular amination, ortho-alkylation, ortho-arylation, ortho-alkenylation, ortho-alkynylation, ortho-acylation, ortho-acetoxylation, ortho-amination, ortho-boronation, meta-arylation and meta-alkylation.

引用

收藏

页码：1867 / 1874

页数：8

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