Acute myelogenous leukemia cells with the MLL-ELL translocation convert morphologically and functionally into adherent myofibroblasts

被引：6

作者：

Tashiro, Haruko ^{[1
]}

Mizutani-Noguchi, Mitsuho ^{[1
]}

Shirasaki, Ryosuke ^{[1
]}

Shirafuji, Naoki ^{[1
]}

机构：

[1] Teikyo Univ, Sch Med, Dept Hematol Oncol, Itabashi Ku, Tokyo 1738606, Japan

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2010年 / 391卷 / 01期

关键词：

MLL; ELL; Myofibroblast; CD133; Cancer stem cell; ACUTE MYELOID LEUKEMIAS; GROWTH-FACTOR; STEM-CELLS; GENE; EXPRESSION; CLONING; 11Q23; RNA; T(11-19)(Q23-P13.1); IDENTIFICATION;

D O I：

10.1016/j.bbrc.2009.11.104

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Bone marrow-myofibroblasts, a major component of bone marrow-stroma, are reported to originate from hematopoietic stem cells We show in this paper that non-adherent leukemia blasts can change into myofibroblasts When myeloblasts from two cases of acute myelogenous leukemia with a fusion product comprising mixed lineage leukemia and RNA polymerase II elongation factor, were Cultured long term, their morphology changed to that of myofibroblasts with similar molecular characteristics to the parental myeloblasts The original leukemia blasts, when cultured on the leukemia blast-derived myofibroblasts, grew extensively Leukemia blasts can create their own microenvironment for proliferation (C) 2009 Elsevier Inc. All rights reserved

引用

页码：592 / 597

页数：6

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