Effect of restraint and footshock stress and norepinephrine treatment on gastric emptying in rats

被引：0

作者：

Tsukada, F ^{[1
]}

Nagura, Y ^{[1
]}

Abe, S ^{[1
]}

Sato, N ^{[1
]}

Ohkubo, Y ^{[1
]}

机构：

[1] Tohoku Pharmaceut Univ, Dept Radiopharm, Aoba Ku, Sendai, Miyagi 9818558, Japan

来源：

BIOLOGICAL & PHARMACEUTICAL BULLETIN | 2003年 / 26卷 / 03期

关键词：

restraint stress; footshock stress; norepinephrine; gastric emptying;

D O I：

暂无

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

We investigated the effects of restraint and footshock stress and norepinephrine treatment on gastric emptying. The gastric emptying was significantly inhibited by restraint stress. beta(3)-adrenergic antagonist canceled the inhibition of gastric emptying caused by restraint stress, while beta(1)-, beta(2)-, alpha(1)-, and alpha(2) -adrenergic antagonists did not affect the inhibition. Norepinephrine treatment also inhibited gastric emptying. The inhibition by norepinephrine treatment was canceled by beta(1)-, beta(2)-, and beta(3)-adrenergic antagonists, but not by alpha(1)- and alpha(2)-adrenergic antagonists. On the other hand, footshock stress did not affect gastric emptying. These results suggest that beta(3)-adrenoceptors play an important role in the inhibition of gastric emptying caused by restraint stress, while nonspecific beta-adrenoceptors are involved in that caused by norepinephrine treatment.

引用

页码：368 / 370

页数：3

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