Palladium-Catalyzed Decarboxylative sp-sp2 Cross-Coupling Reactions of Aryl and Vinyl Halides and Triflates with α,β-Ynoic Acids using Silver Oxide

被引：134

作者：

Kim, Hyunseok ^{[1
,2
]}

Lee, Phil Ho ^{[1
,2
]}

机构：

[1] Kangwon Natl Univ, Dept Chem, Natl Res Lab Catalyt Organ React, Chunchon 200701, South Korea

[2] Kangwon Natl Univ, Inst Mol Sci & Fus Technol, Chunchon 200701, South Korea

来源：

ADVANCED SYNTHESIS & CATALYSIS | 2009年 / 351卷 / 17期

关键词：

cross-coupling reaction; decarboxylation; silver salts; Sonogashira reaction; ONE-POT SYNTHESIS; COPPER-FREE; TERMINAL ALKYNES; SONOGASHIRA REACTION; ACETYLENE DERIVATIVES; ROOM-TEMPERATURE; AMINE-FREE; BROMIDES; SUZUKI; HECK;

D O I：

10.1002/adsc.200900502

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Palladium-catalyzed decarboxylative sp-sp(2) cross-coupling reactions of aryl and vinyl halides and triflates with alpha,beta-ynoic acids using silver oxide have been developed. A variety of alpha,beta-ynoic acids were readily decarboxylated in the presence of silver oxide and then, generated in situ, silver acetylides were coupled with electrophiles in the presence of a palladium(0) catalyst under neutral conditions, producing either symmetrical or unsymmetrical diarylacetylenes, arylalkylacetylenes and arylvinylacetylenes in good to excellent yields.

引用

页码：2827 / 2832

页数：6

共 59 条

[1] AN EFFICIENT PALLADIUM-CATALYZED REACTION OF VINYL AND ARYL HALIDES OR TRIFLATES WITH TERMINAL ALKYNES [J].