Crosstalk between cancer-associated fibroblasts and immune cells in cancer

被引：82

作者：

An, Yuanyuan ^{[1
]}

Liu, Fengtian ^{[1
]}

Chen, Ying ^{[1
]}

Yang, Qing ^{[1
]}

机构：

[1] China Med Univ, Dept Gynecol & Obstet, Shengjing Hosp, Shenyang 110004, Liaoning, Peoples R China

来源：

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE | 2020年 / 24卷 / 01期

关键词：

cancer; cancer-associated fibroblasts; immune cells; tumour microenvironment; CARCINOMA-ASSOCIATED FIBROBLASTS; TO-MESENCHYMAL TRANSITION; ACTIVATION PROTEIN-ALPHA; PHASE-II TRIAL; TUMOR MICROENVIRONMENT; DENDRITIC CELLS; BREAST-CANCER; IMMUNOSUPPRESSION; MACROPHAGES; METASTASIS;

D O I：

10.1111/jcmm.14745

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Multiple studies have shown that cancer-associated fibroblasts (CAFs) play an important role in tumour progression, including carcinogenesis, invasion, metastasis and the chemoresistance of cancer cells. Immune cells, including macrophages, natural killer cells, dendritic cells and T cells, play a dual role in the tumour microenvironment. Although increasing research has focused on studying interactions between distinct cells in the tumour microenvironment, the complex relationships between CAFs and immune cells remain unclear and need further study. Here, we summarize our current understanding of crosstalk between CAFs and immune cells, which may help clarify their diagnostic and therapeutic value in tumour progression.

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页码：13 / 24

页数：12

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