Neuroanatomical correlates of personality traits in temporal lobe epilepsy: Findings from the Epilepsy Connectome Project

被引：11

作者：

Bonet, Charlene N. Rivera ^{[1
]}

Hermann, Bruce ^{[2
]}

Cook, Cole J. ^{[3
]}

Hwang, Gyujoon ^{[3
]}

Dabbs, Kevin ^{[2
]}

Nair, Veena ^{[4
]}

Forseth, Courtney ^{[2
]}

Mathis, Jedidiah ^{[5
,6
]}

Allen, Linda ^{[7
]}

Almane, Dace N. ^{[2
]}

Arkush, Karina ^{[8
]}

Birn, Rasmus ^{[1
,3
,9
]}

Conant, Lisa L. ^{[7
]}

DeYoe, Edgar A. ^{[5
,6
,10
]}

Felton, Elizabeth ^{[2
]}

Humphries, Colin J. ^{[7
]}

Kraegel, Peter ^{[7
]}

Maganti, Rama ^{[2
]}

Nencka, Andrew ^{[5
,6
]}

Nwoke, Onyekachi ^{[11
]}

Raghavan, Manoj ^{[7
]}

Rozman, Megan ^{[7
]}

Shah, Umang ^{[8
]}

Sosa, Veronica N. ^{[8
]}

Struck, Aaron F. ^{[2
]}

Tellapragada, Neelima ^{[4
]}

Ustine, Candida ^{[7
]}

Ward, B. Douglas ^{[10
]}

Prabhakaran, Vivek ^{[1
,2
,4
]}

Binder, Jeffrey R. ^{[7
,10
]}

Meyerand, Mary E. ^{[1
,3
,4
]}

机构：

[1] Univ Wisconsin, Neurosci Training Program, Madison, WI 53706 USA

[2] Univ Wisconsin, Dept Neurol, Madison, WI 53706 USA

[3] Univ Wisconsin, Dept Med Phys, 1530 Med Sci Ctr, Madison, WI 53706 USA

[4] Univ Wisconsin, Dept Radiol, Madison, WI 53706 USA

[5] Froedtert, Dept Radiol, Milwaukee, WI USA

[6] Med Coll Wisconsin, Milwaukee, WI 53226 USA

[7] Med Coll Wisconsin, Dept Neurol, Milwaukee, WI 53226 USA

[8] Aurora St Lukes Med Ctr, Neurosci Innovat Inst, Aurora, CO USA

[9] Univ Wisconsin, Dept Psychiat, Madison, WI 53706 USA

[10] Med Coll Wisconsin, Dept Biophys, Milwaukee, WI 53226 USA

[11] Med Coll Wisconsin, Sch Pharm, Milwaukee, WI 53226 USA

来源：

EPILEPSY & BEHAVIOR | 2019年 / 98卷

基金：

美国国家卫生研究院;

关键词：

Temporal lobe epilepsy; Personality; Big; 5; traits; NEO-Five Factor Inventory; INTERICTAL BEHAVIOR; SEIZURE FREQUENCY; WHITE-MATTER; DEPRESSION; NEUROTICISM; EXTROVERSION; MORPHOMETRY; EXPRESSION; INVENTORY; LIFE;

D O I：

10.1016/j.yebeh.2019.07.025

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

Behavioral and personality disorders in temporal lobe epilepsy (TIE) have been a topic of interest and controversy for decades, with less attention paid to alterations in normal personality structure and traits. In this investigation, core personality traits (the Big 5) and their neurobiological correlates in TIE were explored using the Neuroticism Extraversion Openness-Five Factor Inventory (NEO-FFI) and structural magnetic resonance imaging (MRI) through the Epilepsy Connectome Project (ECP). NEO-FFI scores from 67 individuals with TIE (34.6 +/- 95 years; 67% women) were compared to 31 healthy controls (32.8 +/- 8.9 years; 41% women) to assess differences in the Big 5 traits (agreeableness, openness, conscientiousness, neuroticism, and extraversion). Individuals with TLE showed significantly higher neuroticism, with no significant differences on the other traits. Neural correlates of neuroticism were then determined in participants with 11.6 including cortical and subcortical volumes. Distributed reductions in cortical gray matter volumes were associated with increased neuroticism. Subcortically, hippocampal and amygdala volumes were negatively associated with neuroticism. These results offer insight into alterations in the Big 5 personality traits in T1.6 and their brain-related correlates. (C) 2019 Elsevier Inc. All tights reserved.

引用

页码：220 / 227

页数：8

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