Silver-Mediated Direct Amination of Benzoxazoles: Tuning the Amino Group Source from Formamides to Parent Amines

被引：273
作者：
Cho, Seung Hwan [1 ]
Kim, Ji Young [1 ]
Lee, S. Yunmi [1 ]
Chang, Sukbok [1 ]
机构：
[1] Korea Adv Inst Sci & Technol, Taejon 305701, South Korea
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2009年 / 48卷 / 48期
关键词：
amination; benzoxazoles; C-N coupling; formamides; silver; C-H BONDS; INTERMOLECULAR AMINATION; DIRECT ARYLATION; ARYL; FUNCTIONALIZATION; ALKENES; AMINOCARBONYLATION; HYDROAMINATION; AMIDATION; CLEAVAGE;
D O I：
10.1002/anie.200903957
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Formamides or parent amines were used as an amino group source for the silver-mediated amination of benzoxazoles. Although reactions with formamides proceeded at high temperatures, the direct amination with amines took place under much milder conditions (see scheme). Optically active amino groups could also be installed without racemization. © 2009 Wiley-VCH Verlag GmbH & Co. KGaA.
引用
收藏
页码：9127 / 9130
页数：4
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