Use of Letermovir for Salvage Therapy for Resistant Cytomegalovirus in a Pediatric Hematopoietic Stem Cell Transplant Recipient

被引：24
作者：
Kilgore, Jacob T. [1 ]
Becken, Bradford, III [1 ]
Varga, Matthew G. [4 ,5 ]
Parikh, Suhag [2 ]
Prasad, Vinod [2 ]
Lugo, Debra [1 ,3 ]
Chang, Yeh-Chung [1 ,3 ]
机构：
[1] Duke Univ, Div Pediat Infect Dis, 1915 Childrens Hlth Ctr,Box 3499 DUMC, Durham, NC 27710 USA
[2] Duke Univ, Pediat Bone Marrow Transplant Program, Durham, NC 27710 USA
[3] Duke Univ, Pediat Immunocompromised Host Program, Durham, NC 27710 USA
[4] Univ N Carolina, Gillings Sch Global Publ Hlth, Dept Epidemiol, Chapel Hill, NC 27515 USA
[5] Univ N Carolina, Lineberger Comprehens Canc Ctr, Chapel Hill, NC 27515 USA
来源：
JOURNAL OF THE PEDIATRIC INFECTIOUS DISEASES SOCIETY | 2020年 / 9卷 / 04期
基金：
美国国家卫生研究院;
关键词：
cytomegalovirus (CMV); antiviral resistance; letermovir; hematopoietic stem cell transplant; PROPHYLAXIS; REPLICATION; INFECTION;
D O I：
10.1093/jpids/piz050
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
We present here the first published use of letermovir for the treatment of resistant cytomegalovirus (CMV) in a pediatric patient. A 14-year-old girl underwent a double unrelated umbilical cord blood transplantation to treat her sickle cell disease (hemoglobin SS) and developed ganciclovir-resistant CMV DNAemia with end-organ involvement that was treated successfully with a combination of foscarnet and letermovir. After she was transitioned to letermovir monotherapy for secondary prophylaxis, she developed recurrent DNAemia with laboratory-confirmed ganciclovir, foscarnet, and letermovir resistance.
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收藏
页码：486 / 489
页数：4
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