Antitumor and antimetastatic activities of Rhizoma Paridis saponins

被引：91

作者：

Man, Shuli ^{[1
]}

Gao, Wenyuan ^{[1
]}

Zhang, Yanjun ^{[2
]}

Yan, Lulu ^{[1
]}

Ma, Chaoyi ^{[1
]}

Liu, Changxiao ^{[3
]}

Huang, Luqi ^{[4
]}

机构：

[1] Tianjin Univ, Sch Pharmaceut Sci & Technol, Tianjin 300072, Peoples R China

[2] Tianjin Univ Tradit Chinese Med, Tianjin, Peoples R China

[3] State Key Labs Pharmacodynam & Pharmacokinet, Tianjin, Peoples R China

[4] Chinese Acad Med Sci, Inst Chinese Mat Med, Pharmaceut Res Inst, Beijing 100037, Peoples R China

来源：

STEROIDS | 2009年 / 74卷 / 13-14期

基金：

中国国家自然科学基金;

关键词：

Antitumor; Antimetastasis; Rhizoma Paridis saponins; MMPs; TIMP-2; RESISTANT HEPG2 CELLS; POLYPHYLLIN-D; MATRIX METALLOPROTEINASES; PULMONARY METASTASIS; DIOSGENYL SAPONINS; FORMOSANIN-C; CANCER-CELLS; IN-VITRO; APOPTOSIS; LUNG;

D O I：

10.1016/j.steroids.2009.08.004

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Rhizoma Paridis saponins (RPS) have been found to show strong antitumor activity. However, few studies have yet investigated its role on pulmonary metastasis treated with this herb. To investigate the molecular mechanisms related to metastasis, we studied RPS-treated T739 mice using histopathology. immunohistochemistry and reverse transcription polymerase chain reaction. Apoptosis was measured by TUNEL assay. As a result, RPS inhibited tumor growth by inducing apoptosis and upregulated the expression of TIMP-2 and clown-regulated the level of MMP-2 and MMP-9. In conclusion, RPS is a potent anticancer agent that elicits programmed cell death and inhibits metastases in murine lung adenocarcinoma in vivo. (C) 2009 Elsevier Inc. All rights reserved.

引用

页码：1051 / 1056

页数：6

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