Advancing age leads to predominance of inhibitory receptor expressing CD4 T cells

被引：55

作者：

Channappanavar, Rudragouda ^{[1
]}

Twardy, Brandon S. ^{[1
]}

Krishna, Pratima ^{[1
]}

Suvas, Susmit ^{[1
]}

机构：

[1] Oakland Univ, Coll Arts & Sci, Dept Biol, Rochester, MI 48309 USA

来源：

MECHANISMS OF AGEING AND DEVELOPMENT | 2009年 / 130卷 / 10期

关键词：

T cells; Memory; Suppression and costimulation; MEMORY; LYMPHOCYTES; RESPONSES; EFFECTOR;

D O I：

10.1016/j.mad.2009.08.006

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Decline in CD4 T cell function is the hallmark of aging. In this study, we compared the proportion and absolute number of inhibitory receptor expressing splenic CD4 T cells in unprimed young (2 months)and aged (20 months) C57BL/6 mice. Our results showed a predominance of PD-1, ICOS and CTLA-4 expressing conventional and regulatory CD4 T cells in aged mice. Furthermore, the expression of these molecules was localized to memory but not naive CD4 T cell subset. Since aging is associated with decline in naive but accumulation of hyporesponsive memory phenotype (MP) CD4 T cell, we hypothesize that inhibitory receptors can account for the senescence noted in MP subset of CD4 T cell. (C) 2009 Elsevier Ireland Ltd. All rights reserved.

引用

页码：709 / 712

页数：4

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