Synthesis and biological evaluation of new N-(2-hydroxy-4(or 5)-nitro/aminophenyl)benzamides and phenylacetamides as antimicrobial agents

被引：44

作者：

Ertan, Tugba

Yildiz, Ilkay ^{[1
]}

Ozkan, Semiha

Temiz-Arpaci, Ozlem

Kaynak, Fatma

Yalcin, Ismail

Aki-Sener, Esin

Abbasoglu, Ufuk

机构：

[1] Ankara Univ, Fac Pharm, Dept Pharmaceut Chem, TR-06100 Ankara, Turkey

[2] Gazi Univ, Fac Pharm, Dept Pharmaceut Microbiol, TR-06330 Ankara, Turkey

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2007年 / 15卷 / 05期

关键词：

antibacterial activity; antifungal activity; benzamide; phenylacetamide;

D O I：

10.1016/j.bmc.2006.12.035

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A new series of N-(2-hydroxy-4(or 5)-nitro/aminophenyl)benzamide and phenylacetamide derivatives (la-In, 2a-2n) were synthesized and evaluated for antibacterial and antifungal activities against Staphylococcus aureus, Bacillus subtilis, Klebsiella pneumoniae, Pseudomonas aeruginosa, Escherichia coli, Candida albicans, and their drug-resistant isolates. Microbiological results indicated that the compounds possessed a broad spectrum of activity against the tested microorganisms at MIC values between 500 and 1.95 mu g/ml. Benzamide derivative Id exhibited the greatest activity with MIC values of 1.95, 3.9, and 7.8 mu g/ml against drug-resistant B. subtilis, B. subtilis, and S. aureus, respectively. (c) 2007 Elsevier Ltd. All rights reserved.

引用

页码：2032 / 2044

页数：13

共 22 条

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