COVID-19 reinfection: prolonged shedding or true reinfection?

被引:39
作者
Falahi, S. [1 ]
Kenarkoohi, A. [2 ]
机构
[1] Ilam Univ Med Sci, Zoonot Dis Res Ctr, Ilam, Iran
[2] Ilam Univ Med Sci, Dept Microbiol, Fac Med, Ilam, Iran
关键词
COVID-19; positive re-test; prolonged shedding; SARS-CoV-2; true reinfection;
D O I
10.1016/j.nmni.2020.100812
中图分类号
R51 [传染病];
学科分类号
100401 ;
摘要
The SARS-CoV-2 pandemic is underway and millions of people have been infected. A large number of patients with COVID-19 have recovered and been discharged. While a number of recovered patients test positive again or even have a recurrence of clinical symptoms. Some researchers believe that a positive retest is related to the long-term persistence of the virus in the body, although there is some evidence in favor of reinfection. In this study, we focus more on the possible reasons for positive retesting, antibody responses, and review of possible reinfection case reports. (C) 2020 The Author(s). Published by Elsevier Ltd.
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页数:4
相关论文
共 22 条
[1]  
Bao L., 2020, BIORXIV, P990226, DOI [DOI 10.1101/2020.03.13.990226, DOI 10.1101/2020.03.13.990226V2, 10.1101/2020.03.13.990226]
[2]   SARS-CoV-2, SARS-CoV, and MERS-CoV viral load dynamics, duration of viral shedding, and infectiousness: a systematic review and meta-analysis [J].
Cevik, Muge ;
Tate, Matthew ;
Lloyd, Ollie ;
Maraolo, Alberto Enrico ;
Schafers, Jenna ;
Ho, Antonia .
LANCET MICROBE, 2021, 2 (01) :E13-E22
[3]   Disease severity dictates SARS-CoV-2-specific neutralizing antibody responses in COVID-19 [J].
Chen, Xiangyu ;
Pan, Zhiwei ;
Yue, Shuai ;
Yu, Fei ;
Zhang, Junsong ;
Yang, Yang ;
Li, Ren ;
Liu, Bingfeng ;
Yang, Xiaofan ;
Gao, Leiqiong ;
Li, Zhirong ;
Lin, Yao ;
Huang, Qizhao ;
Xu, Lifan ;
Tang, Jianfang ;
Hu, Li ;
Zhao, Jing ;
Liu, Pinghuang ;
Zhang, Guozhong ;
Chen, Yaokai ;
Deng, Kai ;
Ye, Lilin .
SIGNAL TRANSDUCTION AND TARGETED THERAPY, 2020, 5 (01)
[4]  
Chu AWH, 2020, CLIN INFECT DIS, DOI [DOI 10.1093/cid/ciaa1275, DOI 10.1093/cid/ciaa149]
[5]  
Deng H J, 2020, Nat Med
[6]  
European Centre for Disease Prevention and Control, 2020, REINF SARS COV CONS
[7]  
Goldman Jason D, 2020, medRxiv, DOI 10.1101/2020.09.22.20192443
[8]   Clinical recurrences of COVID-19 symptoms after recovery: Viral relapse, reinfection or inflammatory rebound? [J].
Gousseff, Marie ;
Penot, Pauline ;
Gallay, Laure ;
Batisse, Dominique ;
Benech, Nicolas ;
Bouiller, Kevin ;
Collarino, Rocco ;
Conrad, Anne ;
Slama, Dorsaf ;
Joseph, Cedric ;
Lemaignen, Adrien ;
Lescure, Francois-Xavier ;
Levy, Bruno ;
Mahevas, Matthieu ;
Pozzetto, Bruno ;
Vignier, Nicolas ;
Wyplosz, Benjamin ;
Salmon, Dominique ;
Goehringer, Francois ;
Botelho-Nevers, Elisabeth .
JOURNAL OF INFECTION, 2020, 81 (05) :821-825
[9]   Asymptomatic Reinfection in 2 Healthcare Workers From India With Genetically Distinct Severe Acute Respiratory Syndrome Coronavirus 2 [J].
Gupta, Vivek ;
Bhoyar, Rahul C. ;
Jain, Abhinav ;
Srivastava, Saurabh ;
Upadhayay, Rashmi ;
Imran, Mohamed ;
Jolly, Bani ;
Divakar, Mohit Kumar ;
Sharma, Disha ;
Sehgal, Paras ;
Ranjan, Gyan ;
Gupta, Rakesh ;
Scaria, Vinod ;
Sivasubbu, Sridhar .
CLINICAL INFECTIOUS DISEASES, 2021, 73 (09) :E2823-E2825
[10]   Persistence and decay of human antibody responses to the receptor binding domain of SARS-CoV-2 spike protein in COVID-19 patients [J].
Iyer, Anita S. ;
Jones, Forrest K. ;
Nodoushani, Ariana ;
Kelly, Meagan ;
Becker, Margaret ;
Slater, Damien ;
Mills, Rachel ;
Teng, Erica ;
Kamruzzaman, Mohammad ;
Garcia-Beltran, Wilfredo F. ;
Astudillo, Michael ;
Yang, Diane ;
Miller, Tyler E. ;
Oliver, Elizabeth ;
Fischinger, Stephanie ;
Atyeo, Caroline ;
Iafrate, A. John ;
Calderwood, Stephen B. ;
Lauer, Stephen A. ;
Yu, Jingyou ;
Li, Zhenfeng ;
Feldman, Jared ;
Hauser, Blake M. ;
Caradonna, Timothy M. ;
Branda, John A. ;
Turbett, Sarah E. ;
Larocque, Regina C. ;
Mellon, Guillaume ;
Barouch, Dan H. ;
Schmidt, Aaron G. ;
Azman, Andrew S. ;
Alter, Galit ;
Ryan, Edward T. ;
Harris, Jason B. ;
Charles, Richelle C. .
SCIENCE IMMUNOLOGY, 2020, 5 (52)