The Prognostic Value of Cyclin D1 Expression in Resected Non-Small-Cell Lung Cancer of Stages I-IIIA - Preliminary Report

Background. Lung cancer is the leading cause of cancer death in the majority of developed counties and in Poland. Cyclin D1 regulates the G1-to-S phase transition and its gene is located on chromosome 11q13. Objectives. The aim of this study was to evaluate the prognostic significance of cyclin D1 expression in primary resected stage I-IIIA non-small-cell lung cancer (NSCLC). Material and Methods. The expression of cyclin D1 in paraffin-embedded tumor tissue from 71 patients (53 men and 18 women, mean age: 59.27 +/- 8.50 years) was measured using a monoclonal antibody to cyclin D1 (NCL-L-Cyclin D1-Gm clone P2D11F11, Novocastra). Results. Forty-one (58%) tumor tissue specimens were positive for cyclin D1. Two distinct patterns of staining were observed, but cytoplasmic staining were found in the majority of cases. The prognostic value of cyclin D1 expression was analyzed in all the examined patients and separately in patients with squamous cell lung cancer and adenocarcinoma and for each stage, but only in stage II was there negative correlation between cyclin D1 expression and survival. Conclusions. Expression of cyclin D1 could be negative prognostic factor in some patients with resected non-small-cell lung cancer (Adv Clin Exp Med 2009, 18, 1, 25-31).