Development of a practical, safe, and high-yielding process for the preparation of enantiomerically pure trans-cyclopropane carboxylic acid

被引：31

作者：

Singh, AK ^{[1
]}

Rao, MN ^{[1
]}

Simpson, JH ^{[1
]}

Li, WS ^{[1
]}

Thornton, JE ^{[1
]}

Kuehner, DE ^{[1
]}

Kacsur, DJ ^{[1
]}

机构：

[1] Bristol Myers Squibb Pharmaceut Res Inst, Proc Res & Dev, New Brunswick, NJ 08903 USA

来源：

ORGANIC PROCESS RESEARCH & DEVELOPMENT | 2002年 / 6卷 / 05期

关键词：

D O I：

10.1021/op0202033

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

A practical, safe, and high-yielding process for the cyclopropanation of a chiral epoxide has been developed using the inexpensive and nonhazardous reagents triethylphosphonoacetate and sodium tert-butoxide.

引用

页码：618 / 620

页数：3

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