Electrospinning of biomimetic fibrous scaffolds for tissue engineering: a review

被引:65
作者
Tan, George Z. [1 ]
Zhou, Yingge [1 ]
机构
[1] Texas Tech Univ, Dept Ind Mfg & Syst Engn, Lubbock, TX 79409 USA
关键词
Biomimetic scaffolds; electrospinning; nanofiber; tissue engineering; MESENCHYMAL STEM-CELLS; GROWTH-FACTOR DELIVERY; MARROW STROMAL CELLS; OF-THE-ART; NANOFIBROUS SCAFFOLDS; OSTEOGENIC DIFFERENTIATION; IN-VITRO; 3-DIMENSIONAL SCAFFOLDS; HYDROGEL SCAFFOLD; DRUG-DELIVERY;
D O I
10.1080/00914037.2019.1636248
中图分类号
TB3 [工程材料学]; R318.08 [生物材料学];
学科分类号
0805 ; 080501 ; 080502 ;
摘要
Fibrous microstructure has drawn extensive attention in tissue engineering due to its common presence in connective and muscle tissues. This paper reviews the latest advances in electrospinning as a nanofiber fabrication technique for biomimetic scaffolds. Specifically, we focus on scaffolds with gradients in element and structure, 3 D nanofiber scaffolds, and hydrogel scaffolds incorporated with nanofibers. Future directions of electrospinning research for tissue engineering are to realize the full potential of integrating the tunable 3 D fibrous microarchitecture in scaffold manufacturing at a clinically relevant scale, and to develop novel micro- and nano-scaffold architecture with modulated functionality for optimal tissue regeneration. [GRAPHICS] .
引用
收藏
页码:947 / 960
页数:14
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